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Table 1 Oncogenic and prognostic gene signatures

From: Comparative expression pathway analysis of human and canine mammary tumors

Signature

Type

Model system

Akt Majumder 2004

Oncogenic

Transgenic mouse prostate over-expressin human AKT1

Androgen Chen 2004

Oncogenic

Treatment of LNCaP prostate cells with R1881

Androgen DePrimo 2002

Oncogenic

Treatment of LNCaP prostate cells with R1881

β-catenin Bild 2006

Oncogenic

Adenovirus infection of human primary mammary epithelial cells (HMECs)

Cell cycle Whitfield 2002

Oncogenic

Synchronized HeLa cell cultures

CyclinD1 Lamb 2003

Oncogenic

Adenovirus infection of MCF-7 breast cancer cells

E2F3 Bild 2006

Oncogenic

Adenovirus infection of human primary mammary epithelial cells (HMECs)

EGFR Creighton 2006

Oncogenic

Stable transfection of MCF-7 breast cancer cells

Hypoxia Chi 2006

Oncogenic

Human cells from different tissues

MAPK Creighton 2006

Oncogenic

Stable transfection of MCF-7 breast cancer cells

MEK Creighton 2006

Oncogenic

Stable transfection of MCF-7 breast cancer cells

Myc Bild 2006

Oncogenic

Adenovirus infection of human primary mammary epithelial cells (HMECs)

Myc Coller 2000

Oncogenic

Conditional Myc-estrogen receptor fusion protein in human primary fibroblast cells

Raf1 Creighton 2006

Oncogenic

Stable transfection of MCF-7 breast cancer cells

Ras Bild 2006

Oncogenic

Adenovirus infection of human primary mammary epithelial cells (HMECs)

Src Bild 2006

Oncogenic

Adenovirus infection of human primary mammary epithelial cells (HMECs)

Tamoxifen Chanrion 2008

Oncogenic

Human primary breast tumors

PTEN Saal 2007

Oncogenic

Human primary breast tumors

70 poor prognosis van't Veer 2002

Prognostic

Human primary breast tumors

ERBB2 Creighton 2006

Prognostic

Stable transfection of MCF-7 breast cancer cells

Grade 1–3 Ivshina 2006

Prognostic

Human primary breast tumors

Proliferation signature Dai 2005

Prognostic

Human primary breast tumors

Wound Chang 2004

Prognostic

Response to serum exposure in fibroblasts from ten anatomic sites