Table 1 Description of genes analyzed in skeletal muscle tissue.
Gene symbol1 | Cellular localization | Biological process |
|---|---|---|
ACACA | Cytoplasm | Fatty acid biosynthesis |
ACLY | Cytosol | Citrate metabolic process |
ACSL1 | Plasma and ER membranes | Fatty acid metabolism |
AGPAT1 | ER membrane | Phosphatidic acid biosynthesis |
CD36 | Plasma membrane | Fatty acid metabolism |
DGAT1 | ER membrane | Triacylglycerol metabolism |
DGAT2 | ER membrane | Triacylglycerol metabolism |
FABP4 | Cytosol | Fatty acid binding, transport |
FADS2 | ER membrane | Unsaturated fatty acid synthesis |
FASN | Cytosol | Fatty acid biosynthesis |
G6PD | Cytosol | Pentose-phosphate shunt |
GPAM | Cytosol, mitochondria | Triacylglycerol biosynthesis |
INSIG1 | ER membrane | Lipid metabolism, cell proliferation |
INSR | Plasma membrane | Insulin receptor signaling |
IRS1 | Cytosol | Insulin receptor signaling |
LPIN1 | Nucleus, ER, cytosol | Phosphatidic acid hydrolysis, transcription |
LPIN2 | ER, cytosol | Phosphatidic acid hydrolysis |
LPIN3 | ER, cytosol | Phosphatidic acid hydrolysis |
MDH2 | Mitochondrial matrix | Tricarboxylic acid cycle, malate metabolic process |
PPARD | Nucleus | Fatty acid beta-oxidation, transcription |
PPARG | Nucleus | Induction of adipocyte differentiation, transcription |
PPARGC1A | Nucleus | Fatty acid beta-oxidation, transcription factor |
PPARGC1B | Nucleus | DNA-dependent regulation of transcription |
PRKAA1 | Cytosol | Fatty acid biosynthesis, signal transduction |
PRKAA2 | Cytosol | Fatty acid biosynthesis, signal transduction |
SCAP | ER membrane, Golgi | SREBP target gene transcription activation |
SCD | ER membrane | Fatty acid biosynthesis |
SLC27A1 | Plasma and ER membranes | Fatty acid transport |
SLC2A4 | Plasma membrane, cytosol | Glucose transport, glucose homeostasis |
SREBF1 | Golgi and ER membranes, nucleus | Transcription regulation |
THRSP | Nucleus | Lipid metabolic process |