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Table 1 Distribution of differential genes in myostatin-null mice vs control mice according to KEGG pathways.

From: Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets

#Entity KEGG

Down regulated genes

N =

Up regulated genes

N =

Unadj. P value

Adj. P value

Phosphatidylinositol signaling system

No genes

0

Inppl1, PIK3R3, PIK3CG PLCG1

   

Insulin signaling pathway

Gsk3b

1

Ppp1cb, PTPRF, PIK3R3, PIK3CG, PRKAR1B

5

1.05E-01

1

mTOR signaling pathway

No genes

0

MO25, PIK3R3, PIK3CG

3

1.09E-01

1

Chronic myeloid leukemia

No genes

0

PIK3R3, PIK3CG, Abl1

3

1.09E-01

1

T cell receptor signaling pathway

No genes

0

PIK3R3, PIK3CG, PLCG1

3

1.09E-01

1

Fructose and mannose metabolism

Akr1e1, PMM2, Khk, OGT

4

No genes

0

1.19E-01

1

ECM-receptor interaction

LAMC3, Col4a2, COL6A1, ITGB8, ITGA9

5

Col4a4

1

2.08E-01

1

Calcium signaling pathway

PDE1B, Camk2a, CAMK4, Cacna1i, HTR2A, ADORA2A

6

PLCG1, Ptgfr

2

2.74E-01

1

Regulation of actin cytoskeleton

Limk1, ARPC4 ITGB8, ITGA9

4

FGF6, Ppp1cb, PIK3R3, PIK3CG, CFL2, Actb, MYL1

7

3.50E-01

1

MAPK signaling pathway

Cacna1i

1

MAP2K7, FGF6, PLA2G6

3

3.51E-01

1

Natural killer cell mediated cytotoxicity

KLRC2

1

PIK3R3, PIK3CG, PLCG1

3

3.51E-01

1

Apoptosis

Atm

1

PIK3R3, PIK3CG, PRKAR1B

3

3.51E-01

1

Wnt signaling pathway

Gsk3b, LRP5, Camk2a, LEF1

4

CCND3

1

3.65E-01

1

Leukocyte transendothelial migration

Cxcl15, Cxcl13

2

PIK3R3, PIK3CG, Actb, PLCG1

4

4.27E-01

1

Cytokine-cytokine receptor interaction

IL23A Cxcl15, CXCR3, IL17, Cxcl13

5

CCL22, CCR7

2

4.40E-01

1

Toll-like receptor signaling pathway

Irf3

1

PIK3R3, PIK3CG

2

6.09E-01

1

B cell receptor signaling pathway

Gsk3b

1

PIK3R3, PIK3CG

2

6.09E-01

1

GnRH signaling pathway

Camk2a

1

MAP2K7, PLA2G6

2

6.09E-01

1

Axon guidance

Limk1, Gsk3b, Epha2

3

SEMA3A, Abl1, CFL2, EFNA4

4

7.10E-01

1

Focal adhesion

LAMC3, Gsk3b, Col4a2, COL6A1, ITGB8, ITGA9

6

CCND3, Ppp1cb, PIK3R3, PIK3CG, Actb, Col4a4

6

1

1

Hedgehog signaling pathway

Gsk3b

1

Gas1

1

1

1

Alzheimer's disease

Gsk3b, Apoe

2

LRP1

1

1

1

  1. N: Number of genes involved in each biological process; Unadj. P value: Unadjusted P value, P value from Fisher's exact test without adjusting for multiple comparisons; Adj. P value: adjusted P value, after correction for multiple testing.