Figure 4

Histopathology data. Representative histopathology findings of bladder biopsies from IC patient 15 (A, B), from IC patient 4 (C), and from control patient 2 (D). (A) Cross-section of an entire biopsy (60× magnification). The HE stain shows a focally accentuated lymphoplasmocytic inflammatory infiltration. The inner bladder surface is denudated from the urothelial lining (lower right), thus showing an ulcer area. (B) Giemsa staining (200×). Arrowheads point to numerous mast cells in the mixed lymphoplasmocytic inflammatory infiltration. Blood vessels show active hyperemia with dilated lumina. There is evidence of a substantial interstitial edema. (C) The HE stain (100×) shows a marginal urothelial layer (on the left) and substantial inflammation in deep areas of the biopsy. (D) The HE stain (100×) shows the urothelial layer on the left side and signs of a mild unspecific subepithelial inflammation.