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Figure 6 | BMC Genomics

Figure 6

From: Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy

Figure 6

p53-regulated pathway analysis using the Ingenuity Pathway Knowledge Base (IPKB). This figure illustrates potential functional relationships of TP53 responsive genes de-regulated in the muscles of Dox-treated Tg(HQK) mice. Direct (solid lines) and indirect (dashed lines) interactions reported for these genes (grey shading) in the IPKB database. Color shading corresponds to the type of de-regulation: red for up-regulated genes, and green for down-regulated genes. The shape of the node indicates the major function of the protein (see key), and a line denotes binding of the products of the two genes while a line with an arrow denotes 'acts on'.

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