Skip to main content

Table 3 List of genes belonging to some of the most significantly de-regulated pathways that have been implicated in toxicity-associated biological processes as resulted by Ingenuity Pathway Analysis (up-regulated are denoted by bold type, down-regulated by plain type)

From: Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy

Toxicity-Associated Process

P-value

Genes

P53 signaling

1.27 × 10-7

BBC3, BIRC5, C12ORF5, CDKN1A, CHEK2, E2F1, GADD45B, GADD45G, GSK3B, HIPK2, PERP, PIK3R5, PMAIP1, PPP1R13B, PRKDC, RB1, TP63, TP53INP1

G1/S transition of the cell cycle

1.53 × 10-7

ABL1, CCNE2, CDK6, CDKN1A, E2F1, E2F2, E2F3, E2F6, GSK3B, HDAC5, RB1, RBL2, SIN3A

Mitochondrial dysfunction

1.04 × 10-5

AIFM1, APP, BACE2, COX6B2, CYB5R3, GPD2, GSR, HTRA2, NDUFAF1, NDUFB5, OGDH, PRDX3, SDHA, SDHB, SNCA, SOD2, UQCRC1, UQCRC2, UQCRFS1

Oxidative Stress

4.11 × 10-5

FOS, GPX1, GSR, GSTA5, GSTM2, GSTM1, NFKB1, NFKB2, PRDX3, SOD2, STAT3