From: Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy
Toxicity-Associated Process | P-value | Genes |
---|---|---|
P53 signaling | 1.27 × 10-7 | BBC3, BIRC5, C12ORF5, CDKN1A, CHEK2, E2F1, GADD45B, GADD45G, GSK3B, HIPK2, PERP, PIK3R5, PMAIP1, PPP1R13B, PRKDC, RB1, TP63, TP53INP1 |
G1/S transition of the cell cycle | 1.53 × 10-7 | ABL1, CCNE2, CDK6, CDKN1A, E2F1, E2F2, E2F3, E2F6, GSK3B, HDAC5, RB1, RBL2, SIN3A |
Mitochondrial dysfunction | 1.04 × 10-5 | AIFM1, APP, BACE2, COX6B2, CYB5R3, GPD2, GSR, HTRA2, NDUFAF1, NDUFB5, OGDH, PRDX3, SDHA, SDHB, SNCA, SOD2, UQCRC1, UQCRC2, UQCRFS1 |
Oxidative Stress | 4.11 × 10-5 | FOS, GPX1, GSR, GSTA5, GSTM2, GSTM1, NFKB1, NFKB2, PRDX3, SOD2, STAT3 |