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Table 4 Genes differentially affected by dichlorvos and fenamiphos exposure

From: Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans

ProbeSet

WBIDa

Geneb

Description

Biological Role

Dicc

Fend

191857_s_at

WBGene00011462

scl-22

SCP-like extracellular protein

 

-1.2

-3.7

189735_at

WBGene00002021

hsp-17

heat shock protein

Stress

2.0

-1.0

190518_at

WBGene00006629

tsp-3

tetraspanin

 

2.5

1.0

184400_at

WBGene00017726

F22H10.2

unknown

 

3.2

1.7

192142_at

WBGene00008084

C44C10.3

major facilitator superfamily transporter

Detoxification

3.6

1.4

180425_s_at

WBGene00017484

F15E6.3

RRM-type RNA binding protein

miRNA regulation

4.0

1.9

180592_s_at

WBGene00021224

clec-209

unknown function – contains c-type lectin domain

 

-2.1

2.0

178843_at

WBGene00008584

F08G5.6

CUB domain containing protein

 

-2.3

4.9

193604_at

WBGene00007455

ugt-22

UDP-glucoronosyl and UDP-glucosyl transferases

Phase 2 enzyme

-1.6

6.7

183703_s_at

WBGene00012788

Y43D4A.2

UDP-glucoronosyl and UDP-glucosyl transferases

Phase 2 enzyme

-1.4

7.9

191418_at

WBGene00013901

ugt-16

UDP-glucoronosyl and UDP-glucosyl transferases

Phase 2 enzyme

-1.8

7.7

189394_at

WBGene00019473

cyp-35A5

cytochrome P450

Phase 1 enzyme

-1.1

15.9

193924_at

WBGene00003997

pgp-3

P-glycoprotein 3

Detoxification

1.0

3.1

190248_s_at

WBGene00004008

pgp-14

P-glycoprotein 14

Detoxification

-1.1

3.3

185525_at

WBGene00015399

cyp-35A1

cytochrome P450

Phase 1 enzyme

1.1

4.3

188031_s_at

WBGene00006890

vem-1

putative steroid membrane receptor – involved in axon guidance

 

1.6

5.7

191066_s_at

WBGene00013906

ugt-5

UDP-glucoronosyl and UDP-glucosyl transferases

Phase 2 enzyme

2.2

5.6

188962_at

WBGene00019234

ugt-8

ugt family, 7TM chemoreceptor

Phase 2 enzyme

1.2

10.4

178316_at

WBGene00007811

C29F7.2

unknown

 

2.0

9.8

188217_at

WBGene00004236

ptr-22

sterol sensing domain protein – patch related

Sterol trafficking

2.4

14.7

189282_at

WBGene00007362

cyp-35C1

cytochrome P450

Phase 1 enzyme

1.8

54.5

189283_s_at

WBGene00007362

cyp-35C1

cytochrome P450

Phase 1 enzyme

2.3

54.7

189512_at

WBGene00015400

cyp-35A2

cytochrome P450

Phase 1 enzyme

3.0

33.2

  1. a- WormBase gene identifier
  2. b- Gene names and descriptions were derived from WormBase, release WS189 [46].
  3. c- Gene expression fold change values for dichlorvos SVM predicted high concentration
  4. d- Gene expression fold change values for fenamiphos high concentration