Table 3 Differentially expressed genes in myostatin propeptide transgenic mice compared with wild-type littermates
Accession No. (UniGene) | Gene symbol | Gene name | Transgenic verse wild-type littermates | |
|---|---|---|---|---|
| Â | Â | Â | -Fold change | P -value |
Genes related to myogeneis | ||||
Mm.16528 | Myog | Myogenin | 2.2 | 0.000244 |
Mm.22763 | Fstl1 | Follistatin-like 1 | 2.3 | 0.000244 |
Mm.34446 | Cdkn1a | Cyclin-dependent kinase inhibitor 1A | 3.4 | 0.00002 |
Mm. 6710 | Rock1 | Rho-associated coil-containing protein kinase 1 | 3.5 | 0.00045 |
Genes of extracellular matrix components | ||||
Mm.22621 | Col1a1 | Procollagen, type I, alpha 1 | 3.7 | 0.000244 |
Mm.4482 | Col1a2 | Procollagen, type I, alpha 2 | 3.4 | 0.000244 |
Mm.147387 | Col3a1 | Procollagen, type III, alpha 1 | 3.6 | 0.000244 |
Mm.10299 | Col5a2 | Procollagen, type V, alpha 2 | 1.9 | 0.000244 |
Mm.30477 | Col5a3 | Procollagen, type V, alpha 3 | 2.1 | 0.001953 |
Mm.2509 | Col6a1 | Procollagen, type VI, alpha 1 | 1.6 | 0.000244 |
Mm.1949 | Col6a2 | Procollagen, type VI, alpha 2 | 2.1 | 0.001221 |
Mm.7562 | Col6a3 | Procollagen, type VI, alpha 3 | 1.9 | 0.000244 |
Mm.193099 | Fn1 | Fibronectin 1 | 2.1 | 0.001221 |
Mm.2608 | Bgn | Biglycan | 2.2 | 0.000244 |
Genes related to protein degradation | ||||
Mm.20863 | Capn3 | Calpain 3 | -1.5 | 0.000732 |
Mm.24778 | Capn7 | Calpain 7 | -1.5 | 0.004443 |
Mm.201535 | Casp7 | Caspase 7 | -1.7 | 0.003759 |
Mm.40986 | Usp25 | Ubiquitin specific protease 25 | -1.5 | 0.002392 |
Mm.40466 | Fbox32 | Atrogin 1/F-box protein 32 | -1.6 | 0.000244 |
Mm.24529 | Ube2d3 | Ubiquitin-conjugating enzyme E2D 3 | -1.5 | 0.000732 |
Mm.78312 | Wwp1 | WW domain containing E3 ubiquitin protein ligase | -1.3 | 0.000732 |
Mm.18472 | Psmc6 | Proteasome 26S subunit, ATPase, 6 | -1.0 | 0.001709 |
Mm.21963 | Psme4 | Proteasome activator subunit 4 | -1.2 | 0.000244 |
Genes for mitochondrial ATP synthesis | ||||
Mm.5545 | Ndufaf1 | NADH dehydrogenase 1 alpha subcomplex, 1 | -1.2 | 0.001953 |
Mm.41926 | Ndufa4 | NADH dehydrogenase 1 alpha subcomplex, 4 | -1.4 | 0.000244 |
Mm.27677 | Ndufa5 | NADH dehydrogenase 1 alpha subcomplex, 5 | -1.3 | 0.000244 |
Mm.29513 | Ndufa7 | NADH dehydrogenase 1 alpha subcomplex, 7, | -1.5 | 0.000244 |
Mm.218595 | Ndufas1 | NADH dehydrogenase Fe-S protein 1 | -1.2 | 0.000732 |
Mm.43162 | Uqcr | Ubiquinol-cytochrome c reductase (6.4 kD) subunit | -1.1 | 0.000244 |
Mm.548 | Cox6c | Cytochrome c oxidase, subunit VIc | -1.0 | 0.000244 |
Mm.29512 | Atpaf1 | ATP synthase mitochondrial F1 complex assembly factor 1 | -1.1 | 0.000585 |
Mm.41 | Atp5o | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | -1.4 | 0.000244 |
Mm.1061 | Fdx1 | adrenodoxin | -1.1 | 0.000732 |
Mm.26949 | Etfa | Electron transferring flavoprotein, alpha polypeptide | -1.1 | 0.000244 |
Carrier proteins | ||||
Mm.10661 | Slc2a4 | Facilitated glucose transporter 4/solute carrier 2 | 1.3 | 0.000244 |
Mm. 4312 | Slc9a1 | Solute carrier family 9, member 1 | 3.5 | 0.000889 |
Mm. 129110 | Slc7a2 | Solute carrier family 7, member 2 | 2.1 | 0.00009 |
Mm. 28937 | Slc39a4 | Solute carrier family 39, member 4 | 3.8 | 0.00002 |
Mm. 22260 | Slc38a4 | Solute carrier family 38, member 4 | 1.6 | 0.00003 |
Mm. 46067 | Slc25a30 | Solute carrier family 25, member 30 | 3.1 | 0.00002 |
Mm. 19325 | Slc162a9 | Solute carrier family 16, member 9 | 2.4 | 0.00448 |
Mm. 28506 | Slc15a4 | Solute carrier family 15, member 4 | 1.5 | 0.00002 |
Mm. 63479 | Slc15a4 | Solute carrier family 15, member 2 | 2.3 | 0.00017 |
Others | ||||
Mm.221164 | Myh6 | Myosin heavy polypeptide 6 | 1.7 | 0.00002 |
Mm157026 | Rsn | Restin | 2.3 | 0.00002 |
Mm.17306 | Tmp3 | Tropomyosin 3, gamma | 1.4 | 0.00077 |
Mm.203875 | Ablim1 | Actin-binding LIM protein | 3.3 | 0.00002 |
Mm.104975 | M6prbp1 | Mannose-6-phosphate receptor binding protein 1 | 1.5 | 0.00003 |
Mm.26053 | Pfkfb3 | 6-phosphfructo-2-kinase/fructose-2,6-biphosphastease 3 | 2.4 | 0.00002 |
Mm.200770 | Gsk3b | Glycogen synthase kinase 3 beta | 1.4 | 0.00002 |
Mm. 36640 | Map3k6 | Mitogen activated protein kinase kinase kinase 6 | 2.2 | 0.00002 |