Table 2 Most common Gene Ontology functional categories †

All genes (Total = 31524)

ΨEs (Total = 284)

DEs (Total = 1341)

GO:0005515, protein binding (5864)

GO:0043167, ion binding (92)*^§

GO:0005515, protein binding (372)

GO:0043167, ion binding (3861)

GO:0003676, nucleic acid binding (74)*^§

GO:0043167, ion binding (349)*

GO:0003676, nucleic acid binding (3251)

GO:0005515, protein binding (34)

GO:0003676, nucleic acid binding (176)

GO:0016787, hydrolase activity (2053)

GO:0016740, transferase activity (18)

GO:0016787, hydrolase activity (105)

GO:0000166, nucleotide binding (1992)

GO:0004872, receptor activity (13)

GO:0004872, receptor activity (84)

GO:0004872, receptor activity (1765)

GO:0000166, nucleotide binding (12)

GO:0000166, nucleotide binding (57)

GO:0016740, transferase activity (1631)

GO:0016491, oxidoreductase activity (11)^§

GO:0016740, transferase activity (36)

GO:0016491, oxidoreductase activity (723)

GO:0016787, hydrolase activity (10)

GO:0030246, carbohydrate binding (35)*

GO:0015075, ion transporter activity (541)

GO:0030246, carbohydrate binding (6)

GO:0005201, extracellular matrix structural constituent (22)*

GO:0008289, lipid binding (420)

GO:0046906, tetrapyrrole binding (3)

GO:0004857, enzyme inhibitor activity (21)

Mus musculus

All genes (Total = 28390)

ΨEs (Total = 209)

DEs (Total = 1079)

GO:0005515, protein binding (5553)

GO:0043167, ion binding (55)*

GO:0005515, protein binding (374)*

GO:0043167, ion binding (3672)

GO:0003676, nucleic acid binding (43)*

GO:0043167, ion binding (321)*

GO:0003676, nucleic acid binding (3382)

GO:0004872, receptor activity (27)^§

GO:0003676, nucleic acid binding (173)

GO:0004872, receptor activity (2779)

GO:0016787, hydrolase activity (16)

GO:0016787, hydrolase activity (114)

GO:0016787, hydrolase activity (2260)

GO:0005515, protein binding (14)

GO:0004872, extracellular matrix (109)

GO:0000166, nucleotide binding (2061)

GO:0016491, oxidoreductase activity (9)

GO:0000166, nucleotide binding receptor activity (91)

GO:0016740, transferase activity (1805)

GO:0004857, enzyme inhibitor activity (7)

GO:0016491, oxidoreductase activity (911)

GO:0000166, nucleotide binding (7)

GO:0016740, transferase activity (51)

GO:0015075, ion transporter activity (598)

GO:0046906, tetrapyrrole binding (6)

GO:0030246, carbohydrate binding (41)*

GO:0008289, lipid binding (401)

GO:0016740, transferase activity (5)

GO:0005201, structural constituent (40)*

GO:0016491, oxidoreductase activity (25)

Rattus norvegicus

All genes (Total = 27302)

ΨEs (Total = 218)

DEs (Total = 993)

GO:0005515, protein binding (2732)

GO:0043167, ion binding (23)

GO:0043167, ion binding (158)*

GO:0043167, ion binding (2238)

GO:0016740, transferase activity (16)^§

GO:0005515, protein binding (155)*

GO:0004872, receptor activity (2063)

GO:0003676, nucleic acid binding (15)

GO:0003676, nucleic acid binding (74)

GO:0003676, nucleic acid binding (1720)

GO:0004872, receptor activity (14)

GO:0016787, hydrolase activity (62)

GO:0000166, nucleotide binding (1406)

GO:0005515, protein binding (12)

GO:0000166, nucleotide binding (46)

GO:0016787, hydrolase activity (1331)

GO:0016787, hydrolase activity (12)

GO:0004872, receptor activity (37)

GO:0016740, transferase activity (1179)

GO:0000166, nucleotide binding (10)

GO:0016740, transferase activity (29)

GO:0016491, oxidoreductase activity (594)

GO:0016491, oxidoreductase activity (6)

GO:0016491, oxidoreductase activity (16)

GO:0015075, ion transporter activity (392)

GO:0046906, tetrapyrrole binding (5)

GO:0030246, carbohydrate binding (16)

GO:0003735, structural constituent of ribosome (284)

GO:0030246, carbohydrate binding (4)

GO:0005201, extracellular matrix structural constituent (14)*