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Table 2 BCR-regulated genes discriminating immature and mature B cells at 2 h.

From: A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering

  

microarrays

qPCR

  

BCR/ctrl

 

BCR/ctrl

Gene symbol

Function

IM

M

M/IM

IM

M

Ptger4

B-cell activation and differentiation

1.7

4.6

2.8

1.8

4.8

Marcksl1

proliferation, cell adhesion, neurosecretion

2.6

6.1

2.4

2.2

4.3

Myc

B-cell proliferation, differentiation, apoptosis

3.8

8.9

2.3

4.1

12.9

Crsp9

proliferation

1.4

3.0

2.1

1.7

3.1

Chchd4

no data

1.6

3.3

2.1

1.7

3.1

Wdr55

rRNA synthesis, cell cycle progression

1.3

2.4

1.9

1.7

1.9

Ifrd1

differentiation, proliferation

1.3

2.2

1.7

1.4

2.3

Eif3s1

T-cell activation

1.3

2.3

1.7

1.7

2.0

Idi1

cholesterol synthesis

1.6

2.7

1.7

1.6

2.3

M6pr

lysosomal enzyme transport

1.4

2.5

1.7

1.1

2.0

Nola2

T-cell activation

1.4

2.3

1.7

1.7

2.2

Pdhx

electron transport

1.8

3.0

1.7

-1.3

-1.4

Hrb

spermiogenesis

1.5

2.3

1.5

1.1

2.5

Lyar

cell growth

1.3

1.9

1.5

1.2

2.7

Irx3

heart and CNS development

-1.0

1.4

1.4

-1.2

1.5

Rpo1-3

cell growth

1.1

1.5

1.4

1.1

1.5

Ptdss1

cell growth

-1.0

1.4

1.4

-1.4

1.4

Stt3b

oligosaccharyltransferase activity

1.9

1.3

-1.5

2.6

-1.3

Plekha2

B-cell receptor signaling

-1.7

-2.6

-1.6

-2.5

-5.4

Fbxo22

no data

1.0

-1.6

-1.6

-1.4

-2.0

Jun

apoptosis, proliferation, differentiation

1.1

-1.6

-1.8

-1.1

-3.4

3110001A13Rik

no data

-1.7

-3.6

-2.1

-1.6

-5.1

Spata13

no data

-1.8

-4.8

-2.7

-2.5

-16.7

Tmem23

apoptosis

-1.9

-5.3

-2.8

-2.8

-20.0

  1. Differentially expressed genes in immature (IM) and mature (M) B cells at 2 h of BCR stimulation identified by two-way ANOVA (P < 0.05). Expression changes are shown as ratios of BCR triggered (BCR) versus control (ctrl) B cells at 2 h. Data are means of at least five replicate microarray experiments and at least two independent triplicate RT-PCR results.