Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer

Table 2 Ingenuity Pathways Analysis: Top canonical pathways.

Pathway	-Log(P-value*)	Ratio**	Molecules	N°
Aminoacyl-tRNA Biosynthesis	3.36E+00	7.14E-02	LARS, WARS, GARS, SARS, QARS, EPRS	6
Role of PKR in Interferon Induction and Antiviral Response	2.84E+00	1.28E-01	CASP9, NFKBIA, NFKBIE (includes EG:4794), APAF1, NFKB2, NFKB1	6
Death Receptor Signaling	2.73E+00	1.08E-01	CASP9, NFKBIA, NFKBIE (includes EG:4794), APAF1, NFKB2, NFKB1, BIRC3	7
Glycine, Serine and Threonine Metabolism	2.31E+00	4.17E-02	PSAT1, PHGDH, GARS, CTH, SARS, SHMT2	6
RAR Activation	2.28E+00	6.04E-02	SRC, PRMT2, RDH11, ADCY3, PRKACA, NFKB2, NFKB1, MAPKAPK2, RBP1, MMP1 (includes EG:4312), PTEN	11

*Fischer's exact test was used to calculate a p-value determining the probability that each canonical pathway assigned to that data set is due to chance alone.
**Number of genes from the dataset that map to the pathway divided by the total number of molecules that exist in the canonical pathway

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