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Table 4 Ingenuity Pathways Analysis: Top Bio Functions - Diseases and Disorders

From: Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer

Category

P-value*

Molecules

N°

Cancer

1.12E-04 to 3.06E-02

RPL22, EPS8, LIF, NME2, SFPQ, CDKN2C, SSH1, PTEN, LIMK1, SERPINB2, SOD2, CASP9, CTSS, POSTN, NEDD4L, BIRC3, EPB41L1, CACNA1G, SOX4, YWHAE, RRAD, FGFR1, L1CAM, MBD2, NFKB2, JUNB, SIP1, ADI1, OGG1, NDN, CCND2, RAPGEF2, BTG2, PRKACA, RUNX1, CYLD, LRIG1, MME, BRD2, ICAM1, GEM, RGS3, BMP2, KLF10, MMP14, MCC, HAX1, SAT1, FKBP1A, EXT1, SEPT9, NFKB1, RPLP0 (includes EG:6175), COMP, EIF4EBP1, PGF, RASSF1, NFKBIA, ANGPTL4, EDN1, FOXO3, TAOK2 (includes EG:9344), MEG3 (includes EG:55384), B4GALT5, MMP1 (includes EG:4312), MUC1, CALR, SRC, PXN, RELB, APAF1, PPP1R15A (includes EG:23645), CEBPB, CLCF1, IGF2R, AFF1, NOV, PLAU

78

Hematological Disease

1.12E-04 to 3.06E-02

LIF, ICAM1, MCC, SFPQ, NFKB1, SERPINB2, PTEN, EIF4EBP1, CASP9, NFKBIA, HLA-C, SRC, RELB, ELL, MAN2A1, NFKB2, JUNB, CEBPB, CLCF1, AFF1, CCND2, BTG2, PRKACA, CYLD, PLAU, RUNX1, LRIG1

27

Immunological Disease

1.12E-04 to 3.06E-02

ICAM1, LIF, BGN, MMP14, BMP2, RELB, CDKN2C, NFKB2, JUNB, NFKB1, RPLP0 (includes EG:6175), CLCF1, PTEN, SOD2, CASP9, CCND2, NFKBIA, BTG2, FOXO3, RUNX1, CYLD, LRIG1, BIRC3, HLA-C

24

Renal and Urological Disease

3.57E-04 to 3.06E-02

SRC, RASSF1, SOD2, EDN1, POSTN, NUPR1, PLAU, LRIG1, SIP1, PTEN

10

Skeletal and Muscular Disorders

6.71E-04 to 3.06E-02

MME, LIF, ICAM1, BMP2, MMP14, EXT1, TNFAIP3, C18ORF10, IDE, NFKB1, PTEN, NR4A3, CASP9, SOD2, NFKBIA, EDN1, CTSS, FOXO3, RPS3, MAPKAPK2, MMP1 (includes EG:4312), HLA-C, SRC, NOX4, PPIF, MITF, BGN, APAF1, L1CAM, NFKB2, CEBPB, NDN, DCTN2, CLIC2, NUP62, PLAU, RUNX1, ATP2B4, C20ORF43, MCTP2

40

  1. *Fischer's exact test was used to calculate a p-value determining the probability that each biological function and/or disease assigned to that data set is due to chance alone.