Figure 3
From: Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits
Figure 3A shows the interaction model for Simulated Data Set 2. The asterisk in a genotype represents a "wild card" indicating that either allele is allowable. Figure 3B and 3C are the KWII and PAI spectra for an effect size of 0.5. All the one-variable containing combinations and the 10 two-variable and 5 three-variable combinations with the highest KWII values are shown. Figure 3D shows the dependence of KWII on effect size for the {E2, P} (open circles), {E1, E2, P} (open triangles) and {E2, 1, 2, P} (open squares). Figure 3E shows the PAI for the {1, 3, P} (open squares) and {2, 4, P} (filled circles) combinations when pairwise LD between SNPs 1 and 3 and SNPs 2 and 4 were varied. The error bars in Figures 3B-E represent the 95th percentile and 5th percentile values. The symbols and the error bars in Figure 3E are difficult to distinguish because the values for both combinations were nearly equal. Figure 3F shows the power of the KWII as a function of effect size for the {E2, P} (open circles), {E1, E2, P} (open triangles) and {E2, 1, 2, P} (open squares) combinations.