Figure 2

Conserved genes and disease genes are not randomly distributed throughout the mouse genome. Panel A: Conserved genes are found to have conserved genes as neighbors more often than expected if gene position was random. The results of 10,000 randomization trials are shown in the histogram, while the observed data (number of conserved genes with at least one conserved neighboring gene) is shown with the red line. Panel B: Disease genes neighbor other disease genes more often than expected by chance. The results of 10,000 randomization trials are shown in the histogram, while the observed data (number of disease genes with at least one disease gene as a neighbor) is shown with the red line.