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Table 4 Differential expression of genes involved in protein synthesis/translation, amino acid metabolism/transport and autophagy in response to UCB treatment in SH-SY5Y cells.

From: A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells

Probe_Id

Gene_Name

Gene_Symbol

FC

Location

Function

 

Protein synthesis/translation

    

201000_at

alanyl-tRNA synthetase

AARS

1.7

cytoplasm

tRNA aminoacylation

202402_s_at

cysteinyl-tRNA synthetase

CARS

1.8

cytoplasm

tRNA aminoacylation

202021_x_at

eukaryotic translation initiation factor 1

EIF1

1.4

cytoplasm

translation initiation factory activity

208290_s_at

eukaryotic translation initiation factor 5

EIF5

1.6

cytoplasm

translation initiation factory activity

208708_x_at

eukaryotic translation initiation factor 5

EIF5

1.5

cytoplasm

translation initiation factory activity

208693_s_at

glycyl-tRNA synthetase

GARS

1.8

cytoplasm

tRNA aminoacylation

213671_s_at

methionyl-tRNA synthetase

MARS

1.5

cytoplasm

tRNA aminoacylation

201475_x_at

methionyl-tRNA synthetase

MARS

1.5

cytoplasm

tRNA aminoacylation

213672_at

methionyl-tRNA synthetase

MARS

1.4

cytoplasm

tRNA aminoacylation

200802_at

seryl-tRNA synthetase

SARS

2.2

cytoplasm

tRNA aminoacylation

200629_at

tryptophanyl-tRNA synthetase

WARS

2.9

cytoplasm

tRNA aminoacylation

200628_s_at

tryptophanyl-tRNA synthetase

WARS

2.5

cytoplasm

tRNA aminoacylation

 

mTOR pathway and autophagy

    

217967_s_at

family with sequence similarity 129, member A

FAM129A

6.9

cytoplasm

not defined

217966_s_at

family with sequence similarity 129, member A

FAM129A

4.0

cytoplasm

not defined

202887_s_at

DNA-damage-inducible transcript 4

DDIT4

4.4

cytoplasm

not defined

208869_s_at

GABA(A) receptor-associated protein like 1

GABARAPL1

1.9

Golgi; ER; cytoplasm

protein binding

211458_s_at

GABA(A) receptors associated protein like 3

GABARAPL3

2.3

microtubule

protein binding

203827_at

WD repeat domain, phosphoinositide interacting 1

WIPI1

2.8

Golgi; autophagic vacuole membrane; cytoplasm

receptor binding

213836_s_at

WD repeat domain, phosphoinositide interacting 1

WIPI1

2.7

Golgi; autophagic vacuole membrane; cytoplasm

receptor binding

 

Amino acid metabolism/transport

    

217678_at

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

SLC7A11

6.8

membrane

amino acid transport

209921_at

solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

SLC7A11

6.6

membrane

amino acid transport

201195_s_at

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

SLC7A5

3.2

membrane

amino acid transport

200924_s_at

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

SLC3A2

3.8

membrane

amino acid transport

209610_s_at

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

SLC1A4

2.3

membrane

amino acid transport

212810_s_at

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

SLC1A4

2.1

membrane

amino acid transport

212811_x_at

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

SLC1A4

2.1

membrane

amino acid transport

212110_at

solute carrier family 39 (zinc transporter), member 14

SLC39A14

1.6

membrane

zinc ion transport

203165_s_at

solute carrier family 33 (acetyl-CoA transporter), member 1

SLC33A1

2.2

ER; membrane

acetyl-CoA transporter activity

203164_at

solute carrier family 33 (acetyl-CoA transporter), member 1

SLC33A1

1.9

ER; membrane

acetyl-CoA transporter activity

202433_at

solute carrier family 35, member B1

SLC35B1

1.6

ER; membrane

carbohydrate transport

221024_s_at

solute carrier family 2 (facilitated glucose transporter), member 10

SLC2A10

1.6

membrane

glucose transport

  1. Genes are sub-categorized according to their GO Biological Process annotation. Fold changes (FC) are fold differences for cells treated with Bf 140 nM versus cells grown in DMSO 0.6% (controls) for 24 h. Affymetrix Probe Set-IDs, gene names and symbol, fold change (FC), cellular location are indicated.