Figure 3

miRNA expression during mammopoiesis is highly correlated. Seven clusters obtained by model-based clustering are displayed in separate panels. (a) Grey lines represent the standardized log₂ expression profiles of individual miRNAs. Black lines correspond to mean cluster profiles. (b) Heatmaps of individual clustered miRNAs. Red and blue indicate high and low standardized log₂ expression, respectively. Within each cluster panel, miRNAs are ordered according to miRNA families with identical seed sequence (position 2-8) (indicated by brackets). miRNAs associated with basal or luminal breast cancer are highlighted in red and blue, respectively. Individual panels correspond to the seven clusters in (a).