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Figure 13 | BMC Genomics

Figure 13

From: Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation

Figure 13

Growth regulatory pathways of the host cell are perturbed by adenovirus. Ad proteins act on the host cell signalling network to uncouple DNA replication from anti-growth signals, senescence and apoptosis. Similar growth deregulation is caused as a result of tumour cell mutations. Therefore, viruses and viral proteins represent a natural system that is used to study growth deregulation programs with the aim of gaining insight into the process of carcinogenesis. Figure adapted from [5].

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