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Table 6 Occurrence of B12 biosynthetic pathways and B12-dependent enzymes in archaea

From: Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization

Phylum

Total organisms

B12-utilizing organisms

B12 biosynthesis pathway

B12-dependent isomerase

B12-dependent methyltransferase

    

MCM/MeaA/ICM*

GM

RNR II

Other MTs

MtrA

Nanoarchaeota

1

-

-

-

-

-

-

-

Crenarchaeota/Thermoproteales

6

6

2

-

-

5

1

-

Crenarchaeota/Desulfurococcales

4

3

-

1

-

2

1

-

Crenarchaeota/Sulfolobales

4

4

4

4

-

4

-

-

Euryarchaeota/Thermoplasmales

4

4

4

4

-

4

-

-

Euryarchaeota/Archaeoglobales

1

1

1

1

-

1

1

-

Euryarchaeota/Halobacteriales

5

5

5

5

2

5

-

-

Euryarchaeota/Methanosarcinales

5

5

5

-

-

4

4

5

Euryarchaeota/Thermococcales

4

4

-

4

-

4

-

-

Euryarchaeota/Methanococcales

5

5

5

-

-

-

3

5

Euryarchaeota/Methanopyrales

1

1

1

-

-

-

-

1

Euryarchaeota/Methanobacteriales

3

3

3

-

-

1

3

3

Euryarchaeota/Methanomicrobiales

4

4

4

-

-

3

2

4

Total

47

45

34

19

2

33

15

18

  1. *: MCM, methylmalonyl-CoA mutase; ICM, isobutyryl-CoA mutase; MeaA, a B12-dependent mutase with sequence similarity to MCM and ICM. There three subfamilies are quite similar and combined as one group in this study. GM, glutamate mutase; RNR II, B12-dependent ribonucleotide reductase; Other MTs, various B12-dependent methyltransferases such as Mta, Mtm, Mtb, Mtt, Mts, Mtv and Mtr systems.