Influence of genetic background on the occurrence of chromosomal rearrangements in Saccharomyces cerevisiae

BMC Genomics

Table 1 Number of revertants obtained in the studied contexts and the corresponding mutation rates.

Strains	No. of revertants or ATCase reactivation events (mutation rate × 10^-10) (95% confidence interval)
	Global	Deletion	Duplication
aUHT	29 1.025 (0.676; 1.373)	20 (69%) 0.707 (0.466; 0.947)	9 (31%)0.317 (0.210; 0.426)
aΔrad52	21 1.69 (1.133; 2.247)	18 (86%) 1.45 (0.974; 1.932)	3 (14%) 0.237 (0.158; 0.314)
aΔrad59	37 1.81 (1.27; 2.35)	20 (54%) 0.977 (0.685; 1.269)	17 (46%) 0.832 (0.584; 1.081)
aΔyku80	22 0.997 (0.604; 1.39)	16 (73%) 0.728 (0.441; 1.015)	6 (27%) 0.269 (0.163; 0.375)
aΔlig4	9 0.204 (0.055; 0.353)	9 (100%) 0.204 (0.055; 0.353)	0

The mutation rates (mutations/cell/selection) were determined using the maximum-likelihood method described by Lea and Coulson (1949). The 95% confidence limits were calculated using Student's t-test.

ISSN: 1471-2164