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Table 1 Subgroups of up-regulated genes.

From: Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes

Group

Group Size (probe sets)

Group Size (Genes)

NF-κB target genes (Bioinf)

NF-κB target genes (Lit)

ARE

IL-17

2

2

-

-

-

TNF/IL-17

21

21

8 (38%)

1 (5%)

9 (43%)

IL1 + IL17

6

6

-

-

-

IL1 + TNF

141

135

23 (17%)

8 (6%)

24 (18%)

IL1 + TNF/IL17

89

80

9 (11%)

18 (23%)

15 (19%)

IL-17 + TNF/IL17

4

4

-

-

-

IL17 + TNF

4

4

-

-

-

TNF + TNF/IL17

17

16

-

-

-

TNF + IL1 + TNF/IL17

177

151

39 (26%)

35 (23%)

25 (17%)

TNF + IL17 + TNF/IL17

2

2

-

-

-

IL1 + IL17 + TNF/IL17

12

10

-

-

-

TNF + IL1 + IL17

14

14

-

-

-

Up-regulated by all stimuli

(TNF/IL-17, IL-17, TNF, IL-1)

48

40

23 (58%)

21 (53%)

15 (38%)

All expressed genesa

14.988

9.828

1369(14%)

311 (3%)

2076 (21%)

  1. Probe sets and gene numbers are indicated as well as frequency of NF-κB transcription factor binding site (separated for the bioinformatic and literature based approach) and the frequency of AU rich elements (ARE). Groups with less than 20 genes have been excluded from the analysis.
  2. a This group comprises all genes which show at least one valid expression value
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BMC Genomics

ISSN: 1471-2164

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