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Table 2 Known dioxin-inducible genes

From: Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

Resistant Collective

Sensitive Collective

   

H/W

LnA

L-E

LnC

   

FC log2

padj

FC log2

padj

FC log2

padj

FC log2

padj

Gene ID

Symbol

Full Name

6.3

3.2 × 10-9

5.4

8.2 × 10-8

6.8

2.2 × 10-12

6.2

8.9 × 10-10

25375

Aldh3a1

aldehyde dehydrogenase 3 family, member A1

6.4

1.3 × 10-4

6.1

1.0 × 10-6

6.6

3.3 × 10-8

6.4

1.8 × 10-9

24296

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

1.2

2.0 × 10-5

1.2

1.6 × 10-5

1.1

1.5 × 10-6

1.1

1.9 × 10-5

24297

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

3.9

6.8 × 10-5

3.5

4.9 × 10-7

5.3

4.4 × 10-6

4.9

7.8 × 10-6

25426

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

1.2

4.4 × 10-3

1.1

1.9 × 10-3

1.9

3.8 × 10-4

1.4

1.9 × 10-3

83619

Nfe2l2

nuclear factor, erythroid derived 2, like 2

3.7

3.2 × 10-5

2.5

1.4 × 10-4

2.4

4.9 × 10-5

2.6

4.5 × 10-5

24314

Nqo1

NAD(P)H dehydrogenase, quinone 1

2.3

1.2 × 10-3

1.8

1.3 × 10-3

2.5

1.6 × 10-4

2.2

1.7 × 10-4

310467

Tiparp

TCDD-inducible poly(ADP-ribose) polymerase

  1. Transcriptional responses after 19-hour TCDD exposure in the four rat strains/lines were identified using Affymetrix RAE230A arrays followed by data pre-processing and statistical testing using linear models. Twenty-five Type-I genes (similar response to TCDD in all four strains/lines) were identified. These included several well-established AHR-regulated and dioxin-inducible genes, supporting the validity of the array experiments. For each strain/line, the fold-change (FC in log2 space) in mRNA levels between treated and control rats as well as the significance levels are presented.
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