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Table 3 Type-II gene responses 19 hours after TCDD exposure

From: Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

Resistant Collective

Sensitive Collective

   

H/W

LnA

L-E

LnC

   

FC log2

padj

FC log2

padj

FC log2

padj

FC log2

padj

Gene ID

Symbol

Full Name

-0.3

7.3 × 10-2

-0.4

1.1 × 10-2

-0.7

5.7 × 10-4

-0.3

3.0 × 10-3

25368

Adk

adenosine kinase

0.4

2.2 × 10-2

0.2

5.6 × 10-2

0.6

6.2 × 10-3

0.4

4.8 × 10-3

305338

Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

-0.4

1.4 × 10-1

-0.3

6.8 × 10-2

-0.8

1.5 × 10-3

-0.5

2.9 × 10-3

25698

Ass1

argininosuccinate synthetase 1

0.3

7.3 × 10-2

0.4

1.1 × 10-2

0.4

7.3 × 10-3

0.4

1.4 × 10-3

116550

Atp5c1

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

-0.9

6.5 × 10-2

-0.6

4.8 × 10-2

-0.9

4.3 × 10-3

-0.8

4.5 × 10-3

64828

B4galnt1

beta-1,4-N-acetyl-galactosaminyl transferase 1

0.3

1.6 × 10-1

0.2

6.0 × 10-2

0.6

4.3 × 10-3

0.7

1.5 × 10-3

113948

Bbs2

Bardet-Biedl syndrome 2 homolog (human)

0.3

3.0 × 10-1

0.5

5.7 × 10-2

0.5

1.0 × 10-3

0.6

2.2 × 10-3

292027

Cfdp1

craniofacial development protein 1

-0.2

2.3 × 10-1

-0.3

7.1 × 10-2

-0.6

1.0 × 10-3

-0.6

1.5 × 10-3

85251

Col18a1

collagen, type XVIII, alpha 1

-0.3

3.2 × 10-1

-0.5

6.6 × 10-2

-0.9

1.7 × 10-4

-0.4

9.4 × 10-3

266682

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

-0.4

2.8 × 10-1

-0.5

3.3 × 10-2

-0.9

7.8 × 10-5

-0.5

2.2 × 10-3

286904

Cyp4f4

cytochrome P450, family 4, subfamily f, polypeptide 4

0.4

1.2 × 10-2

0.2

5.0 × 10-2

0.4

1.2 × 10-3

0.4

3.5 × 10-3

362912

Derl1

Der1-like domain family, member 1

0.6

6.6 × 10-2

0.3

2.3 × 10-2

0.6

1.7 × 10-3

0.6

6.5 × 10-4

691956

Derl2

Der1-like domain family, member 2

-0.4

1.5 × 10-1

-0.3

1.0 × 10-1

-0.4

5.9 × 10-3

-0.5

9.7 × 10-3

25313

Egf

epidermal growth factor

0.3

6.3 × 10-1

1.1

2.0 × 10-1

1.2

3.3 × 10-4

0.6

9.8 × 10-3

171402

Elovl6

ELOVL family member 6, elongation of long chain fatty acids (yeast)

-0.3

2.9 × 10-1

-0.3

7.2 × 10-2

-0.7

1.0 × 10-3

-0.5

9.4 × 10-3

29580

Fdft1

farnesyl diphosphate farnesyl transferase 1

-0.3

3.7 × 10-1

-0.3

4.3 × 10-2

-0.7

4.2 × 10-4

-0.4

4.1 × 10-3

297029

Gstk1

glutathione S-transferase kappa 1

-0.5

9.3 × 10-2

-0.2

1.8 × 10-1

-0.7

6.9 × 10-3

-0.4

3.0 × 10-3

81869

Gstm7

glutathione S-transferase, mu 7

-1.3

7.2 × 10-3

-1.0

1.1 × 10-3

-1.1

3.4 × 10-2

-1.2

1.2 × 10-2

85255

Hacl1

2-hydroxyacyl-CoA lyase 1

-0.2

6.3 × 10-1

-0.3

1.8 × 10-1

-0.7

6.5 × 10-4

-0.7

2.2 × 10-3

24439

Hagh

hydroxyacyl glutathione hydrolase

-0.6

2.5 × 10-2

-0.2

2.1 × 10-1

-0.6

2.7 × 10-3

-0.7

4.7 × 10-3

25116

Hsd11b1

hydroxysteroid 11-beta dehydrogenase 1

0.5

1.5 × 10-1

0.3

1.1 × 10-1

0.9

1.0 × 10-3

0.6

4.8 × 10-3

84013

Hsd17b12

hydroxysteroid (17-beta) dehydrogenase 12

1.4

5.1 × 10-3

0.5

3.9 × 10-3

0.7

4.3 × 10-2

0.9

1.5 × 10-2

25663

Il1r1

interleukin 1 receptor, type I

-0.6

3.7 × 10-2

-0.3

1.8 × 10-1

-0.7

3.8 × 10-3

-0.8

6.1 × 10-4

690745

LOC690745

MOCO sulphurase C-terminal domain containing-like

0.2

8.5 × 10-1

-0.5

4.2 × 10-2

-0.8

8.5 × 10-4

-0.5

4.8 × 10-3

497794

Mug1

murinoglobulin 1

-0.4

8.6 × 10-2

-0.4

4.1 × 10-2

-0.6

3.6 × 10-3

-0.6

8.6 × 10-3

29227

Nfib

nuclear factor I/B

-0.5

9.3 × 10-2

-0.6

3.2 × 10-2

-1.2

1.0 × 10-3

-0.5

1.4 × 10-3

680451

Nrbp2

nuclear receptor binding protein 2

-0.2

6.1 × 10-1

-0.4

1.0 × 10-2

-0.6

2.5 × 10-4

-0.5

3.4 × 10-3

94267

Nudt4

nudix (nucleoside diphosphate linked moiety X)-type motif 4

1.0

1.6 × 10-2

0.7

4.2 × 10-2

0.7

4.6 × 10-3

1.2

1.9 × 10-5

171564

Pbld

phenazine biosynthesis-like protein domain containing

0.4

4.5 × 10-2

0.3

4.2 × 10-2

0.4

7.6 × 10-3

0.4

1.5 × 10-3

308061

Pdcd6

programmed cell death 6

0.7

5.1 × 10-3

0.7

2.0 × 10-4

0.4

1.1 × 10-1

0.7

1.3 × 10-2

114209

Phyh

phytanoyl-CoA 2-hydroxylase

0.6

1.6 × 10-2

0.4

5.2 × 10-2

0.5

2.7 × 10-3

0.8

7.7 × 10-5

64390

Prpsap1

phosphoribosyl pyrophosphate synthetase-associated protein 1

-0.3

3.3 × 10-1

-0.4

7.0 × 10-2

-0.6

4.3 × 10-3

-0.5

2.9 × 10-3

315655

Rdx

radixin

-0.2

1.2 × 10-1

-0.4

1.5 × 10-2

-0.6

5.0 × 10-3

-0.5

1.3 × 10-3

363160

RGD1311563

similar to Oligosaccharyl transferase 3 CG7748-PA

0.1

3.1 × 10-1

0.2

1.1 × 10-1

1.4

7.3 × 10-3

0.7

4.1 × 10-4

315611

Scn4b

sodium channel, type IV, beta

-0.3

3.7 × 10-1

-0.6

2.9 × 10-2

-1.2

6.8 × 10-4

-0.9

5.1 × 10-3

25216

Sdc1

syndecan 1

0.4

8.4 × 10-2

0.4

2.3 × 10-2

0.5

4.3 × 10-3

0.6

7.9 × 10-3

680891

Sf3b5

splicing factor 3b, subunit 5

-0.2

5.9 × 10-1

-0.3

3.5 × 10-2

-0.5

2.5 × 10-4

-0.4

2.6 × 10-3

81536

Sgpp1

sphingosine-1-phosphate phosphatase 1

-0.8

2.1 × 10-2

-0.6

5.0 × 10-2

-0.7

4.2 × 10-4

-0.7

2.0 × 10-3

79111

Slc27a5

solute carrier family 27 (fatty acid transporter), member 5

0.6

2.1 × 10-2

0.4

1.7 × 10-2

0.5

4.4 × 10-3

0.7

3.7 × 10-4

500707

Tc2n

tandem C2 domains, nuclear

0.2

4.4 × 10-1

0.3

5.0 × 10-2

0.3

7.0 × 10-3

0.5

3.0 × 10-3

367909

Tceal8

transcription elongation factor A (SII)-like 8

-0.2

3.7 × 10-1

-0.3

8.3 × 10-2

-0.5

3.3 × 10-3

-0.4

3.4 × 10-3

170907

Tpo1

developmentally regulated protein TPO1

0.7

2.2 × 10-2

0.3

7.4 × 10-2

0.6

7.5 × 10-3

0.6

4.1 × 10-3

362890

Tspan31

tetraspanin 31

-0.2

3.8 × 10-1

-0.1

7.8 × 10-1

-0.4

6.3 × 10-3

-0.4

3.4 × 10-3

362696

Ttc7

tetratricopeptide repeat domain 7

-0.1

7.8 × 10-1

-0.3

6.2 × 10-2

-0.5

5.4 × 10-3

-0.5

4.5 × 10-3

363869

Ubl3

ubiquitin-like 3

-0.9

1.5 × 10-1

-0.5

2.9 × 10-1

-0.9

1.5 × 10-4

-1.1

1.3 × 10-3

117522

Xpnpep2

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

0.3

4.6 × 10-2

0.4

1.2 × 10-2

0.6

1.3 × 10-3

0.7

4.3 × 10-3

360389

Zfp422

zinc finger protein 422

  1. Transcriptional responses after 19 hours TCDD exposure in the four rat strains/lines were identified using Affymetrix RAE230A arrays followed by data pre-processing and statistical testing using linear models. Type-II genes were identified as those where both strains/lines in one collective showed statistically significant responses to TCDD (padjusted < 0.01) in the same direction, while both strains/lines in the other collective showed no response (padjusted > 0.01). For each strain/line, the fold-change (FC in log2 space) in mRNA levels between treated and control rats as well as the significance levels are presented. Genes are sorted alphabetically by gene symbol.
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BMC Genomics

ISSN: 1471-2164

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