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Figure 4 | BMC Genomics

Figure 4

From: Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

Figure 4

Correlation between senescence scoring and cell line compound sensitivities. Regression analysis was performed comparing DAS and mSS senescence scores derived from the NCI60 panel (figure 3, dataset GSE5846) with GI50 values for each cell line for ~1500 compounds reported in [44]. Representative regressions for DAS and compound NSC300288 (A) and mSS and compound NSC638279 (B) are shown. (C) Quantification of all compounds showing significant regression against DAS or mSS. (D) Characterisation of relationship between DAS/mSS and drug sensitivity. The slope of the regression for each significant DAS/mSS related compound was quantified. The figure shows the mean value across all significant compounds. (E) Activity modelling for significant compounds. Compounds were assigned predicted activity based on a decision tree model relating chemical similarity to a dataset of compounds with known activities. The proportion of compounds from DAS or mSS significant lists falling into each activity category is shown normalised to target class representation in the total compound set.

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BMC Genomics

ISSN: 1471-2164

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