Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

Table 1 Gene expression changes and senescence signatures.

Originating Senescence Signatures	Genes	Expression Direction in Senescence
	p16	Increase
	HMGA1	Increase
	HMGA2	Increase
	HIRA	Increase
	ASF1a	Increase
DAS Biomarkers	H2AFY	Increase
[16, 17, 19–23]	H2AFY2	Increase
	PML	Increase
	MMP3	Increase
	53BP1	Increase
	p21	Increase
	Ki67	Decrease
	IL6	Increase
	IL8	Increase
	PAI1	Increase
	IGFBP3	Increase
	IGFBP5	Increase
	IGFBP7	Increase
	IL1A	Increase
mSS Biomarkers	CXCR2	Increase
[11, 12, 14, 15]	IGF1	Decrease
	IGF2	Decrease
	WNT2	Decrease
	CAMP	Increase
	STMN1	Increase
	EEF1A1	Increase
	IGF2R	Increase
	TGFB1	Increase

ISSN: 1471-2164