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Figure 5 | BMC Genomics

Figure 5

From: Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation

Figure 5

Model of physiological and pathological functions of RAGE signaling. Combination of gene expression profiling and computational approaches revealed that RAGE is not necessary for the initial response after stimulation, but absolute required for sustaining altered gene transcription. This is mainly due to the impact of RAGE-mediated signaling on expression and activity of transcription factors such as E2F. Thereby, RAGE modulates the kinetic of transcript levels of genes implicated in tissue homeostasis, inflammation, and cancer.

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