Figure 1

A multi-species comparison of Giardia to other protozoan pathogens. A comparison of the divergence between different species of protozoan pathogens. The following pairs of species were compared: T. cruzi (non-Esmeraldo) - T. brucei; P. falciparum - P. knowlesi; G. intestinalis WB - G. intestinalis GS; G. intestinalis GS - G. intestinalis P15; T. parva - T. annulata; G. intestinalis WB - G. intestinalis P15; L. major - L. infantum; C. parvum - C. hominis. The vertical axis shows the cumulative frequency of the ortholog count and the horizontal axis shows the corresponding amino acid identity. A steeper curve to the right indicate that the species pair is more closely related compared to a species pair to the left. In this comparison, C. parvum and C. hominis are the closest related species, whereas T. cruzi and T. brucei are the most distantly related based on protein similarity. G. intestinalis P15 and WB have a divergence close to what can be observed between L. major and L. infantum. G. intestinalis WB and GS have a divergence close to what is observed between T. parva and T. annulata. The ortholog relationships were established using reciprocal BLASTP and the protein identities were extracted from the BLAST outputs. Sequence data was downloaded from EuPathDB.