Figure 4

Heatmaps of expression profiles for regulated genes, sharing enriched annotation categories, during treatment with zinc supplementation for 0.3, 1, 4, 7, and 14 days. Gene expression is given as fold-change ranging from -4 (green) to +4 (red, see colour bar) in zinc supplementated fish relative to controls at each time point. Gene trees were generated using Spearman Rank Correlation and Average Linkage Clustering. The represented categories are (A) 'nervous system development', (B) 'cell fate commitment', (C) 'lipid biosynthetic pathway', (D) 'sequence-specific DNA-binding', (E) 'cell cycle process', (F) 'positive regulation of biological process', (G) 'response to steroid hormone stimulus', and (H) 'iron binding' as detailed in Figure 3.