Figure 3

Modelling of the listerial metabolism during intracellular replication. The main anabolic and catabolic pathways of L. monocytogenes are shown. Transporters for cations (green), anions (pink), carbohydrates and organic acids (orange), and amino acids and peptides (blue) are depicted in the membrane. Numbers in red indicate key affected enzymes, areas shaded in light red key pathways for intracellular survival according to this study. Transporters are generally referred to TransportDB [56] and the Transport Classification Database tcdb [57], their known specificities were discussed [58]. Note the incomplete TCA pathway and a short-cut in the urea cycle [13, 14]. Abbreviations: AICAR, 5-amino-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide; E4P, erythrose-4-phosphate; DHF, dihydrofolate; G-1-P, glucose-1-phosphate; DahP, 3-deoxy-D-arabino-heptulosonate-7-phosphate; F-6-P, fructose-6-phosphate; G-6-P, glucose-6-phosphate; GAP, glyceraldehyde-3-phosphate; OAA, oxaloacetate; aKB, 2-oxoglutarate; 6PGluco, 6-phosphogluconate; PRPP, 5-phosphoribosyl 1-pyrophosphate; R5P, ribose-5-phosphate; Ru5P, ribulose-5-phosphate; S7P, sedaheptulose-7-phosphate; TCA, tricarboxylic acid; TCOylcine, 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine; X5P, xylulose-5-phosphate; L-Asp4Semialdehyde, L-Aspartate 4-semialdehyde; GSH, glutathione.