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Table 2 Summary of differentially expressed genes in the livers of female Sprague-Dawley rats following p.o. exposure to TCDD, PCB126 and PCB153 for 13 and 52 weeks

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

13 Week Subchronic Exposure Experiment

 

Exposure Group

Number of Differentially Expressed Genes

100 ng/kg/day TCDD

103 (18)

1000 ng/kg/day PCB126

371 (164)

1000 μg/kg/day PCB153

39 (0)

52 Week Chronic Exposure Experiment

 

Exposure Group

Number of Differentially Expressed Genes

100 ng/kg/day TCDD

299 (22)

30 ng/kg/day PCB126

52 (1)

300 ng/kg/day PCB126

128 (15)

1000 ng/kg/day PCB126

216 (171)

1000 μg/kg/day PCB153

47 (1)

  1. Shown are the total number of probe sets exhibiting a ≥ 2-fold change in expression and a p-value < 0.05 following the specified treatments. In parenthesis are probe sets that are still significant following Benjamini-Hochberg false discovery rate correction.