Table 4 Relative fold change in genes differentially expressed in livers of female Sprague-Dawley rats following 13 weeks and 52 weeks of p.o. exposure to 1000 ng/kg/day PCB126 and 100 ng/kg/day TCDD, and 24 h post-exposure to 5 μg/kg TCDD, p.o.

Cyp1a1

Cytochrome P450, family 1, subfamily a, polypeptide 1

1140*

1026*

1551*

1277*

127881**

YES (8)

YES (11)

Cyp1b1

Cytochrome P450, family 1, subfamily b, polypeptide 1

519*

743*

2091*

1288*

121^d**

YES (9)

YES (7)

Ceacam10

CEA-related cell adhesion molecule 10

369*

620*

976*

973*

8.5**

NO

N/P

Cox8h

Cytochrome c oxidase subunit VIII-H (heart/muscle)

66*

312*

24*

27*

N/D

NO

N/A

Nqo1

NAD(P)H dehydrogenase, quinone 1

21*

20

9*

8*

37.0**

YES (7)

YES (2)

Ugt1a7

UDP glycosyltransferase 1 family, polypeptide A7

14*

85*

40*

33*

24.5**

YES (4)

YES (2)

Ugt1a6

UDP glycosyltransferase 1 family, polypeptide A6

11*

56*

16*

12*

383.6**

YES (6)

YES (2)

Cyp1a2

Cytochrome P450, family 1, subfamily a, polypeptide 2

7*

3*

2*

2

38.5**

NO

YES (3)

Enpp2

Ectonucleotide pyrophosphatase/phosphodiesterase 2

6*

6*

5*

4

2.6**

YES (1)

NO

Exoc3

Exocyst complex component 3

6*

32*

21*

23*

8.1**

NO

YES (7)

Aldh3a1

Aldehyde dehydrogenase family 3, member A1

5*

57*

1493*

1156*

10.2**

YES (2)

YES (5)

Me1

Malic enzyme 1

4*

3

4*

3

2.4**

YES (2)

YES (2)

Trib3

Tribbles homolog 3 (Drosophila)

2*

8*

13*

16

2.2**

YES (1)

YES (3)

Tsc22d1

TSC22 domain family, member 1

-2

-2

-6*

-4

1.5

YES (4)

YES (2)

Gls2

Glutaminase 2 (liver, mitochondrial)

-2*

-3

-6*

-4

-2.5**

YES (2)

YES (3)

Zfp354a

Zinc finger protein 354A

-2

-2

-8*

-5

-5.3

YES (1)

YES (1)

Alas1

Aminolevulinic acid synthase 1

-2*

-2

-3

-3

-1.6

N/A

YES (2)

Phyh2

Phytanoyl-CoA 2-hydroxylase 2

-2

-4

-3*

-3

-1.6

YES (1)

YES (1)

Ca2

Carbonic anhydrase 2

-3

-8*

-6*

-3

-1.9^d

NO

YES (4)

Sfxn1

Sideroflexin 1

-3*

-3*

-3*

-2

-2.9

NO

YES (2)

Mtmr7

Myotubularin related protein 7

-3*

-3

-5*

-5

-3.0**

N/A

YES (2)

Pik3c2g

Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide

-3

-2

-3*

-3

-1.5

NO

NO

Acsm2

Acyl-CoA synthetase medium-chain family member 2

-3

-26

-12*

-14

-3.9

YES (2)

N/P

Slc29a1

Solute carrier family 29 (nucleoside transporters), member 1

-3*

-3

-3*

-2*

-2.1

YES (2)

YES (1)

Cadps

Ca2+-dependent secretion activator

-3

-3

-3

-3

-2.6**

YES (1)

YES (5)

Hal

Histidine ammonia lyase

-3

-2

-17*

-10

-1.3

YES (2)

NO

Cyp3a13

Cytochrome P450, family 3, subfamily a, polypeptide 13

-3

-139*

-610*

-606*

-5.6^d**

NO

N/P

Ptprd

Protein tyrosine phosphatase, receptor type, D

-3*

-2

-3

-2

-1.9

YES (4)

YES (2)

Ces3

Carboxylesterase 3

-3*

-9

-9*

-6

-2.8^d

NO

YES (2)

Mgst3

Microsomal glutathione S-transferase 3

-3

-3

-4*

-4

-3.4**

YES (7)

YES (4)

Serpina7

Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7

-3

-15

-21*

-16

-3.3^d

NO

NO

Nr0b2

Nuclear receptor subfamily 0, group B, member 2

-3*

-2

-3*

-2

-6.4**

NO

YES (2)

Aspg

Asparaginase homolog (S. cerevisiae)

-4*

-10

-41*

-28

-4.1**

YES (8)

N/P

Il33

Il33 interleukin 33

-4*

-3

-3*

-3

-2.1**

NO

N/P

Ptprn

Protein tyrosine phosphatase, receptor type, N

-4

-3

-4*

-3

-1

YES (2)

YES (1)

Srd5a1

Steroid 5 alpha-reductase 1

-4

-6

-14*

-11

-2.0^d**

YES (1)

YES (8)

Enpp3

Ectonucleotide pyrophosphatase/phosphodiesterase 3

-4*

-4*

-5*

-4

-2.3**

NO

NO

Pdp2

Pyruvate dehydrogenase phosphatase isoenzyme 2

-4

-3

-9*

-3

-1.8

YES (1)

YES (3)

Ugt1a1

UDP glycosyltransferase 1 family, polypeptide A1

-5*

-3

-3*

-3

-1.3

YES (4)

YES (4)

Slc13a3

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

-5

-7

-4*

-5

-3.3^d**

YES (3)

YES (1)

Resp18

Regulated endocrine-specific protein 18

-7

-6

-15*

-34

-5.7**

NO

N/A