Table 5 Relative fold change in genes differentially expressed in human intrahepatic cholangiocarcinoma (ICC) and the hepatic gene expression profiles of rats exposed to TCDD, PCB126, and PCB153 p.o. for 52 weeks

NM_144755

Trib3

Tribbles homolog 3 (Drosophila)

TRIB3

18

N/C

16

13

N/C

NM_016988

Acp2

Acid phosphatase 2, lysosomal

ACP2

2

N/C

3

2

N/C

NM_021261

Tmsb10

Thymosin, beta 10

TMSB10

2

N/C

2

N/C

N/C

NM_017059

Bax

Bcl2-associated X protein

BAX

4

N/C

2

N/C

N/C

NM_019287

Apob

Apolipoprotein B

APOB

N/C

-3

-9

N/C

N/C

NM_019185

Gata6

GATA binding protein 6

GATA6

-4

-5

-3

-4

N/C

NM_013219

Cadps

Ca2+-dependent secretion activator

CADPS

N/C

-16

-3

-3

N/C

NM_012886

Timp3

Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)

TIMP3

-11

-3

-2

N/C

N/C

NM_017158

Cyp2c7

Cytochrome P450, family 2, subfamily c, polypeptide 7

CYP2C9

N/C

-3

-2

-2

N/C

NM_134432

Agt

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

AGT

N/C

-6

-2

N/C

N/C

NM_053598

Nudt4

Nudix (nucleoside diphosphate linked moiety X)-type motif 4

NUDT4

-3

N/C

-2

N/C

N/C

NM_013029

St8sia3

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

ST8SIA3

-2

N/C

-2

N/C

N/C

NM_012596

Lepr

Leptin receptor

LEPR

-8

N/C

-2

N/C

N/C

NM_022501

Crip2

Cysteine-rich protein 2

CRIP

-9

N/C

-3

-3

N/C

NM_031132

Tgfbr2

Transforming growth factor, beta receptor II

TGFBR2

-4

N/C

-3

N/C

N/C

NM_001025271

Sfpq

Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

SFPQ

-5

N/C

-3

N/C

N/C

NM_001007235

Itpr1

Inositol 1,4,5-triphosphate receptor 1

ITPR1

-3

N/C

-3

-3

N/C

NM_053328

Bhlhb2

Basic helix-loop-helix domain containing, class B2

BHLHB2

-4

N/C

-4

N/C

N/C

NM_001013137

Cxcl14

Chemokine (C-X-C motif) ligand 14

CXCL14

-11

N/C

-4

-10

N/C

NM_031561

Cd36

Cd36 antigen

CD36

-5

N/C

-6

-4

N/C

NM_031135

Klf10

Kruppel-like factor 10

KLF10

-4

N/C

-10

N/C

N/C

NM_022251

Enpep

Glutamyl aminopeptidase

ENPEP

-2

N/C

-12

-5

N/C

NM_031648

Fxyd1

FXYD domain-containing ion transport regulator 1

FXYD1

-14

N/C

N/C

-2

N/C

NM_053698

Cited2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

CITED2

-4

N/C

N/C

-4

N/C