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Table 1 P-DUDES gene expression in cancer and cancer models

From: A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins

gene

direction

tissue

mechanism proposed

reference

CCDC80

DOWN

rat epithelial cells neoplastically transformed by β-catenin.

 

[9]

CCDC80

DOWN

thyroid neoplastic cell lines and tissues

 

[14]

CCDC80

DOWN

colon and pancreatic cancer cells.

mediates growth inhibition

[9]

SRPX

DOWN

highly malignant human pulmonary neuroendocrine tumors.

 

[10]

SRPX

DOWN

prostate carcinomas.

 

[89]

SRPX

DOWN

colorectal neoplasms.

 

[90]

SRPX

DOWN

lung adenocarcinomas.

 

[91]

SRPX

DOWN

colon adenocarcinomas.

 

[92]

SRPX

DOWN

endothelial cells, myeloma

 

[93]

SRPX

DOWN

stromal fibroblast cells from liver metastases of colorectal cancer

 

[94]

SRPX

NA

SRPX knock-out mouse embryonic fibroblasts

involvement in the maturation process of autophagy

[13]

SRPX

NA

malignant tumors including lymphomas, lung adenocarcinomas and hepatomas

Tumors appear in SRPX-knock out mice

[11]

SRPX

NA

human cancer cell lines.

apoptosis induction in human cancer cell lines; both the P-DUDES and the sushi regions necessary

[12]

SRPX2

NA

endothelial cells

mediator of angiogenesis

[20]

SRPX2

NA

 

ligand for uPAR

[19]

SRPX2

UP

gastric cancer

enhancing cellular migration and adhesion through FAK signaling

[16, 17]

SRPX2

UP

pro-B leukemia cells

 

[5]