Table 3 Similarity between known thioredoxins and the novel Thx-fold families
Pfam domain | Top PDB hit (PDB ID) | p-value | Top Scop hit | p-value | Top Pfam hit | p-value | Comment |
|---|---|---|---|---|---|---|---|
ArsD | 3ktb_A Arsenical resistance operon trans-acting repressor | 0 | d1iloa c.47.1.1 | 8.7E-10 | pfam00462 Glutaredoxin | 9.2E-07 | Structure known, 3ktb, has Thx fold, as seen by Fatcat and Vast |
DUF929 | 1fo5_A Thioredoxin | 0.00015 | d1fo5a c.47.1.1 | 0.00021 | PF00085 Thioredoxin | 0.00026 | Â |
DUF1094 | 3fhk_A YphP disulfide isomerase | 0 | d1f9ma c.47.1.1 | 8.8E-06 | pfam09085 Adhes-Ig_like pfam00085 Thioredoxin | 1.3E-05 0.00035 | Structure known, 3fhk, has Thx fold as stated by the authors |
DUF1223 | 2axo_A Hypothetical protein | 0 | d2axoa1 c.47.1.19 | 0 | pfam00462 Glutaredoxin | 7.5E-08 | Structure known, 2axo, classified as Thx in Scop |
DUF1462 | 1xg8_A Hypothetical protein | 0 | d1xg8a c.47.1.17 | 0 | pfam05768 DUF836 Glutaredoxin-like | 1.5E-05 | Structure known, 1xg8, classified as Thx in Scop |
DUF2703 | 1ilo_A Conserved hypothetical protein | 8.6E-06 | d1iloa c.47.1.1 | 1.7E-05 | PF03135 CagE_TrbE_VirB pfam00462 Glutaredoxin | 0.00024 0.00061 | Â |
DUF2847 | 3iv4_A Putative oxidoreductase | 0 | d1ep7a c.47.1.1 | 1.8E-10 | pfam00085 Thioredoxin | 2.1E-08 | Structure known, 3iv4, has Thx fold, as stated by the authors |
DUF3088 | 3ir4_A Glutaredoxin 2 | 1.6E-06 | d1k0ma2 c.47.1.5 | 1.6E-06 | PF02798 GST_N | 0.00012 | Â |
TrbC_Ftype | 1dby_A Chloroplast thioredoxin | 6.7E-07 | d1dbya c.47.1.1 | 5.8E-07 | PF00085 Thioredoxin | 4.1E-06 | Â |