Figure 9

Theoretical assessment of diagnostic probe performance based on alignments of probe sequences to recently published enterobacterial genomes. The image plot summarises lengths of longest stretches of consecutive matching (green scale) and cross-matches (red scale) of probes to new genomes. Grey colour indicates an expectation of matching without the observation of matches. Fields coloured in light red represent weak similarities that will not lead to cross-hybridisation. The genus level categories show high similarity to corresponding probes, in downstream levels few cross-matching was observed between E. coli pathotypes. The cross-matching goes back to only few probes.