Table 2 Selected GO category and genes that are altered at 35 days, and comparison with changes at 7 days.
GO category | Gene Name | Gene Symbol | 35 days | 7 days |
|---|---|---|---|---|
| Â | Â | Â | (Nan vs Veh) | (Nan vs Veh) |
Calcium/calmodulin-mediated signaling | Regulator of Calcineurin 2 (Down syndrome critical region gene 1-like 1) | RCAN2 | -1.69 | 1.26 |
| Â | Calcium/calmodulin-dependent protein kinase II, alpha | Camk2a | -3.23 | -1.30 |
| Â | Calcineurin B, type1 | Ppp3r1 | 2.11 | 1.12 |
Cell cycle | G0/G1 switch gene 2 | G0s2 | 2.07 | -1.45 |
| Â | Transducer of ERBB2, 2 | Tob2 | -1.43 | 1.03 |
Cell proliferation | Protein phosphatase 1, catalytic subunit, beta isoform | PPP1CB | -1.92 | 1.02 |
| Â | EGL nine homolog 3 | EGLN3 | -1.64 | 1.12 |
Development | Clusterin | Clu | 2.52 | 1.05 |
| Â | Developmentally regulated GTP binding protein 1 | Drg1 | 3.97 | 1.24 |
| Â | Dicer1 | Dicer1 | -2.00 | -1.14 |
| Â | Sortilin 1 | SORT1 | -1.82 | 1.50 |
G-protein coupled receptor protein signaling pathway | Regulator of G-protein signaling 2 | RGS2 | 1.96 | 1.08 |
| Â | Guanine nucleotide binding protein, alpha 12 | GNA12 | 1.94 | 1.07 |
| Â | GNAS complex locus | GNAS | -2.38 | 1.24 |
Growth factor | Apolipoprotein D | Apo D | 14.73 | 3.00 |
| Â | Osteoglycin | OGN | 2.60 | 1.27 |
Muscle development | Myotrophin | Mtpn | 1.92 | 1.02 |
| Â | AE binding protein 1 | AEBP1 | 3.44 | 2.60 |
Muscle contraction | Myosin binding protein H | Mybph | -1.82 | 1.15 |
Nervous system development | Myelin basic protein | MBP | 12.06 | 2.85 |
Protein kinase | Protein kinase, AMP-activated, gamma 3 non-catalytic subunit | Prkag3 | -1.64 | 1.05 |
|  | Protein kinase inhibitor, alpha | Pkiα | 2.47 | -1.08 |
| Â | Protein kinase, AMP-activated, a1 catalytic unit | Prkaa1 | 1.93 | -1.14 |
| Â | Sprouty protein with EVH-1 domain 1, related sequence | SPRED1 | 2.93 | 1.58 |
Response to wounding | Chemokine (C-C motif) ligand 7 | CCL7 | 1.70 | 1.05 |
| Â | Chemokine (C-C motif) receptor 1 | CCR1 | 1.55 | 1.23 |
Transcription | Early growth response 1 | Egr1 | 2.28 | -2.33 |
| Â | Early growth response 2 | Erg2 | 2.54 | -3.85 |
| Â | Early growth response 3 | Egr3 | 2.29 | -4.76 |
| Â | Forkhead box protein O1A | FOXO1 | -2.22 | 1.22 |
| Â | Transforming, acidic coiled-coil containing protein 2 | TACC2 | -2.38 | 1.41 |
| Â | Nuclear protein 1 | Nupr1 | 2.17 | 1.37 |
| Â | Heat shock transcription factor 4 | HSF4 | -1.72 | 1.10 |
| Â | carboxy-terminal domain, RNA polymerase II, polypeptide A | Ctdsp1 | -1.54 | 1.06 |
| Â | Grainyhead-like 1 | Grhl1 | -2.70 | 1.22 |
| Â | Human immunodeficiency virus type I enhancer binding protein 1 | HIV EP1 | 1.72 | 1.16 |
| Â | TSC22-related-inducible leucine zipper protein 2 | TSC22 | -1.19 | 2.30 |
Translation | Eukaryotic elongation factor-2 kinase | Eef2k | -2.44 | 1.24 |
| Â | DNA-damage-inducible transcript 4-like | REDD2/DDIT4L | -1.72 | -1.32 |
Ubiquitin -Proteasome Pathway | Sequestosome 1 | SQSTM1 | -1.92 | 1.37 |
| Â | UBIQUITIN-CONJUGATING ENZYME E2H | Ube2h | 1.97 | 1.12 |
Wnt signaling pathway | Casein kinase 1, alpha 1 | Csnk1a1 | -2.44 | -1.37 |