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Table 1 MicroRNAs whose expressions were significantly changed by ENU in at least one post-treatment time point.

From: Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

MicroRNA

Day 1

Day 3

Day 7

Day 15

Day 30

Day 120

Function

let-7b

   

+

  

Ectopic expression of let-7b reduced HMGA2 expression and cell proliferation in a lung cancer cell line [33].

miR-106b

   

+

  

miR-106b was up-regulated in several human tumors compared with adjacent normal tissues and formed a negative-feedback loop with cell cycle regulator E2F1 [43].

miR-130a

   

+

  

Expression of miR-130a was significantly up-regulated in primary glioblastomas compared with normal peripheral brain tissue [44].

miR-130b

   

+

  

miR-130b showed increased expression in patients with primary WHO grade II gliomas that spontaneously progressed to WHO grade IV secondary glioblastomas [45]. miR-130b was also up-regulated in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation [46].

miR-135b

    

+ +

+ +

miR-135b expressed was increased in patients with post-surgery elevation of prostate-specific antigen (chemical relapse), as compared with patients with non-relapse disease [47].

miR-138

   

+

  

miR-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines [34].

miR-144

   

+

  

Introduction of miR-144 affected caspase activation in TRAIL-induced apoptosis pathway [48].

miR-150

-

     

Control of B cell differentiation by targeting the transcription factor c-Myb [49].

miR-219

   

+

  

miR-219 displayed dysregulated expression in human tongue carcinomas [50].

miR-222

  

+

+

  

miR-222 was up-regulated in atypical teratoid-rhabdoid tumors [51].

miR-301a

   

+

  

miR-301a expression was significantly differentiated in smoker versus non-smoker [52].

miR-302c*

  

- - -

- - -

  

ND

miR-32

   

+

  

Over-expression of miR-32 was associated with poor outcome of human kidney cancer [53].

miR-335-5p

  

+

+

  

miR-335 was highly expressed in pediatric acute myeloid leukemia [54].

miR-337-5p

   

+

  

ND

miR-339-5p

 

+

    

ND

miR-34a

+

+ +

+

+ + +

+

 

Regulation of p53-mediated apoptosis [32].

miR-34b-5p

+

+ +

+ + +

+ + +

+ +

 

Induction of cell cycle arrest by joining p53 network [55].

miR-34c

 

+

+ +

+ +

+

 

Induction of cell cycle arrest by joining p53 network [35].

miR-369-5p

  

- - -

- - -

  

miR-369-5p was up-regulated in mesenchymal stem cells propagation [56].

miR-411

  

-

   

ND

miR-423-5p

 

+

 

+

  

miR-423-5p was involved in muscle development and growth and showed greatest in the neonate development stage [57].

miR-434-5p

  

-

   

ND

miR-451

   

+

  

miR-451 expression was up-regulated in multidrug resistant cancer cell lines [58].

miR-453

  

-

-

 

+

A variant affecting miR-453's putative target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women [59].

miR-466d-5p

   

+ +

  

ND

miR-484

   

+

  

miR-484 was involved in adrenal tumorigenesis [60].

miR-487b

   

+

  

ND

miR-590-3p

  

+ + +

   

miR-590-3p and other miRNAs were suggested to mediate control of autoimmune gene expression [61].

miR-590-5p

    

+

 

miR-590 was involved in regulating the expression of transforming growth factor TGF-beta1 and its receptor TGF-betaRII [62].

miR-672

  

+ +

+

  

ND

miR-677

  

+

+

  

ND

miR-700

   

+

  

ND

miR-707

   

+

  

ND

miR-762

   

+

  

miR-762 was up-regulated in tumor tissue induced by DMBA [10].

miR-871

   

-

  

ND

miR-875-3p

  

- - -

   

ND

miR-877

   

+

  

ND

miR-883a-5p

   

-

  

ND

miR-93

   

+

  

miR-93 was over-expressed in human T-cell leukemia virus 1- transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients [46].

miR-681

     

+

ND

miR-205

     

+

miR-205 expression was down-regulated in breast cancer, but up-regulated in other types of cancer including lung cancer, bladder cancer and ovarian cancer [63].

miR-142-3p

     

+

miR-142-3p was over-expressed in childhood B-cell precursor acute lymphoblastic leukemia [64].

  1. Note: miRNAs with p value < 0.01 and fold change >2.0 were considered significantly changed. The symbols +, ++, and +++; or -, - -, and - - - indicate that the miRNA was up- or down-regulated at a magnitude of 2-4, 4-6, and >6 fold, respectively. No symbol is given if the miRNA was not significantly changed. ND means not determined.