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Figure 1 | BMC Genomics

Figure 1

From: Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment

Figure 1

Structural comparison between a medium to high quality model of 3-Hydroxiacyl-CoA Dehydrogenase from Trypanosoma cruzi and one homologous and one analogous structure from the PDB (classified according to the AnEnΠ pipeline). 1(a): structural alignment of the T. cruzi (Tc00.1047053510105.240) protein model (yellow) and a homologous protein (PDB 1F14) from Homo sapiens (blue), detailing its active site residues S137, H158 and N208 according to [30]. The alignment was performed by Swiss-PDB Viewer (v4.0.1) [31]. 1(b): structure of T. cruzi (Tc00.1047053510105.240) model (yellow) and the analogous enzyme (PDB 1SO8) from H. sapiens (green). The putative active site residues S154, H175 and N225 of T. cruzi protein (yellow) are presented in detail, inferred by the alignment in Figure 1(a), and the H. sapiens (green) active site (S155, Y168 and K172) from [44]. The images were generated using VMD (Visual Molecular Dynamics - v1.8.6) software [45]

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