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Table 3 Key milestones of computational protein complex detection

From: Computational approaches for detecting protein complexes from protein interaction networks: a survey

Methods

Main contributions

MCODE [27]

MCODE pioneered the computational detection of protein complexes from PPI networks.

MCL [30, 31]

MCL is a widely used method [33–36] with good convergence and robustness [32]

Krogan et al. [33]

They provided and exploited a comprehensive TAP dataset for computational protein complex detection.

Gavin et al. [3]

In addition to providing a TAP dataset widely used for protein complex detection, they described the inherent organization of protein complexes with core-attachment structures.

Sharan et al. [78–80]

They systematically conducted cross-species analysis of PPI networks to derive evolutionary information for protein complex detection.