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Table 3 Putative virulence factors found in GGS_124 and their prevalence in the SDSE isolates based on the results of PCR analyses.

From: Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)

S. dysgalactiae subsp. equisimilis GGS_124

Best hit strain

PCR analysis

Locus tag

Product name

Length (aa)

LPXTG motif

% Identity

Strain

Product name

Reference sequence

GGS _124

168

GGS _117

170

164

GGS _118

169

163

     

Streptococcus equi

          
 

fimbrial subunit

   

subsp. zooepidemicus

fimbrial subunit

         

SDEG_0157

Protein

645

IPNTG

40.48

MGCS10565

protein

YP_002124169.1

Yes

x

x

x

x

x

x

x

 

T-antigen-like fimbrial

   

Streptococcus equi

T-antigen-like fimbrial

         
 

structural subunit

   

subsp. zooepidemicus

structural subunit

         

SDEG_0158

protein

315

IPKTG

49.84

MGCS10565

protein

YP_002124168.1

Yes

Yes

Yes

x

x

x

x

x

SDEG_0180

hypothetical protein

184

 

-

No hit

-

-

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 

hypothetical

    

hypothetical

         
 

membrane associated

   

Streptococcus pyogenes

membrane-associated

         

SDEG_0267

protein

242

 

44.35

MGAS2096

Protein

YP_601272.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 

cell surface serine

   

Streptococcus

          

SDEG_0574

endopeptidase

216

 

49.36

Agalactiae

CspA

AAN85092.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

     

Streptococcus equi

          
 

cell wall surface

   

subsp. zooepidemicus

cell wall surface

         

SDEG_0805

anchor family protein

486

LPKAG

43.73

MGCS10565

anchor family protein

YP_002123384.1

Yes

Yes

x

x

Yes

x

x

Yes

     

Streptococcus equi

          
     

subsp. zooepidemicus

histidine triad protein

         

SDEG_0918

histidine triad protein

153

 

51.35

MGCS10565

HtpA

YP_002123384.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 

complement inhibitor

   

Streptococcus pyogenes

complement inhibitor

         

SDEG_0932

protein

226

 

47.92

MGAS2096

protein

YP_601343.1

Yes

x

x

x

x

Yes

x

x

 

nisin resistance

   

Streptococcus

nisin resistance

         

SDEG_0979

protein, putative

322

 

42.17

agalactiae 2603V/R

Protein

NP_687984.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

     

Streptococcus

          

SDEG_1327

YaeC family protein

280

 

49.47

agalactiae 2603V/R

YaeC family protein

NP_687791.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 

probable surface

    

probable surface

         
 

antigen negative

   

Streptococcus suis

antigen negative

         

SDEG_1429

regulator

185

 

52.22

98HAH33

regulator Par

YP_001200806.1

Yes

x

Yes

Yes

Yes

Yes

x

Yes

     

Streptococcus pyogenes

          

SDEG_1480

hypothetical protein

299

LPVTG

33.33

MGAS6180

hypothetical protein

YP_280631.1

Yes

x

Yes

Yes

Yes

Yes

Yes

Yes

SDEG_1511

hypothetical protein

546

 

27.59

Streptococcus suis

hypothetical protein

ABQ42885.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

     

Streptococcus uberis

          

SDEG_1573

adhesion protein

661

LPKTG

38.8

UT888

adhesion protein

ABB52003.1

Yes

Yes

x

x

x

x

x

Yes

SDEG_1601

hypothetical protein

249

 

-

No hit

-

-

Yes

x

Yes

x

x

Yes

x

x

     

Streptococcus pyogenes

          

SDEG_1773

hypothetical protein

210

FPSTG

37.96

M1 GAS

hypothetical protein

NP_268519.1

Yes

Yes

Yes

x

x

Yes

Yes

Yes

     

Streptococcus sanguinis

          

SDEG_1969

hypothetical protein

234

 

32.77

SK36

hypothetical protein

YP_001035903.1

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

 

protein F2-like

   

Streptococcus equi

          
 

fibronectin binding

   

subsp. zooepidemicus

fibronectin binding

         

SDEG_1984

Protein

528

LPATG

40.46

ATCC 35246

protein

ABC87919.1

Yes

x

x

Yes

Yes

x

Yes

Yes

SDEG_2022

hypothetical protein

106

 

-

No hit

-

-

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

SDEG_2141

hypothetical protein

175

 

-

No hit

-

-

Yes

x

x

x

Yes

x

x

Yes

  1. Genes encoding proteins, which contain predicted signal peptide based on SignalP http://www.cbs.dtu.dk/services/SignalP and the LPXTG motif based on HMMER http://bamics3.cmbi.kun.nl/jos/sortase_substrates/help.html and were not highly homologous to putative virulence factors of GGS_124. Distribution of the putative virulence factors of GGS_124 in the 16 SDSE strains was analyzed by PCR, and the results are presented as SDSE strains in order of decreasing lethality in mice. Yes: PCR analysis postive; x: PCR analysis negative.
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BMC Genomics

ISSN: 1471-2164

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