Skip to main content
Figure 7 | BMC Genomics

Figure 7

From: Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

Figure 7

Comparative analysis of GSTA5 orthologs. (A) QRTPCR verification of the divergent expression of GSTA5 orthologs in human HepG2, mouse Hepa1c1c7 and rat H4IIE cell lines. Fold changes were calculated relative to time-matched vehicle controls. Error bars represent the standard error of measurement for the average fold change and the asterisk (*) indicates p < 0.05. (B) Gene regulatory regions (-10,000 to 1,000 bp relative to the transcription start site [TSS]) were computationally searched for the 5 bp DRE core (GCGTC) and indicated by the grey boxes. Each core was extended by the flanking 7 bp, and the resulting 19 bp sequence (C) was compared to a consensus DRE sequence using a position weight matrix developed from bona fide functional DREs. The shaded rows in (C) indicate the highly similar mouse and rat DRE sequences (Euclidean ≤ 3.0).

Back to article page