Figure 8

Gene interaction network of TCDD-responsive orthologs functionally related to lipid metabolism. Molecules are represented by nodes connected by arrows to indicate either direct or indirect relationships (dotted lines). Colors in the gene expression boxes represent the direction and magnitude of the gene expression responses from the Agilent microarrays. The network visualizes species-conserved and -divergent gene expression responses elicited by TCDD in the human HepG2, mouse Hepa1c1c7 and rat H4IIE cell lines.