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Table 4 Functional enrichment analysis of differentially regulateda genes elicited by TCDD in HepG2 cells using DAVID.

From: Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

Category

Term

Gene count

Fold enrichment

P-value

Enrichment Score: 2.99

   

   GOTERM_BP_3

GO:0009410 ~ response to xenobiotic stimulus

10

8.03

1.54E-06

   GOTERM_BP_3

GO:0006805 ~ xenobiotic metabolic process

9

8.32

4.92E-06

   GOTERM_BP_3

GO:0017144 ~ drug metabolic process

3

3.46

2.13E-01

   GOTERM_BP_3

GO:0006800 ~ oxygen and reactive oxygen species metabolic process

4

1.12

7.00E-01

Enrichment Score: 2.71

   

   GOTERM_BP_3

GO:0022403 ~ cell cycle phase

40

1.80

4.36E-04

   GOTERM_BP_3

GO:0048285 ~ organelle fission

25

2.03

1.35E-03

   GOTERM_BP_3

GO:0000278 ~ mitotic cell cycle

34

1.70

3.07E-03

   GOTERM_BP_3

GO:0022402 ~ cell cycle process

45

1.48

8.10E-03

Enrichment Score: 2.30

   

   GOTERM_BP_3

GO:0006629 ~ lipid metabolic process

70

1.65

3.82E-05

   GOTERM_BP_3

GO:0008610 ~ lipid biosynthetic process

25

1.47

5.48E-02

   GOTERM_BP_3

GO:0044255 ~ cellular lipid metabolic process

37

1.34

6.10E-02

Enrichment Score: 2.03

   

   GOTERM_BP_3

GO:0006790 ~ sulfur metabolic process

15

2.41

3.58E-03

   GOTERM_BP_3

GO:0006518 ~ peptide metabolic process

9

3.20

6.37E-03

   GOTERM_BP_3

GO:0051186 ~ cofactor metabolic process

20

1.91

8.81E-03

   GOTERM_BP_3

GO:0006519 ~ cellular amino acid and derivative metabolic process

28

1.48

3.94E-02

Enrichment Score: 1.63

   

   GOTERM_BP_3

GO:0005975 ~ carbohydrate metabolic process

43

1.55

4.51E-03

   GOTERM_BP_3

GO:0044262 ~ cellular carbohydrate metabolic process

32

1.56

1.40E-02

   GOTERM_BP_3

GO:0016051 ~ carbohydrate biosynthetic process

12

2.09

2.79E-02

   GOTERM_BP_3

GO:0005996 ~ monosaccharide metabolic process

19

1.62

4.67E-02

   GOTERM_BP_3

GO:0046165 ~ alcohol biosynthetic process

6

2.52

8.71E-02

Enrichment Score: 1.57

   

   GOTERM_BP_3

GO:0010817 ~ regulation of hormone levels

17

2.11

6.67E-03

   GOTERM_BP_3

GO:0034754 ~ cellular hormone metabolic process

9

2.87

1.22E-02

   GOTERM_BP_3

GO:0042446 ~ hormone biosynthetic process

4

2.38

2.34E-01

  1. aDifferentially regulated genes with P1(t) > 0.999 and |foldchange| > 1.4
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