Figure 2From: Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulationGene expression differences in absence or presence of ERβ. Top: Heatmap summarizing the effects of ERβ expression of the estrogen responsive transcriptome of MCF-7 cells, showing changes in expression (log2 of the fold-change) of 921 transcripts after cell exposure to 10-8M E2 for the indicated times. Transcripts are grouped as follows: regulated only in wt MCF-7 cells (1), in both cell lines (2) and only in TAP-ERβ cells (3). Bottom: Venn diagram showing the numbers of differentially regulated by E2 in wt MCF-7 only (1), both cell lines (2) or ERβ expressing cells only (3).Back to article page