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Table 4 Expression profiling studies of fission yeast with DNA microarrays - S. pombe Functional Genomics Lab http://www.sanger.ac.uk/PostGenomics/S_pombe/-: modulation of genes belonging to the ubiquitin-proteasome pathway

From: Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast

  

Homolog/Ortholog

Gene name

Annotation

S. cerevisiae

Human

Lub1

Ub proteolysis

DOA1/UFD3

PLAA

ubi4

Ub-attachment to target

UBI4

UBC

ubc6

Ub ligase

UBC6

UBE2J2

SPAC22A12.14c

Ub protease

-

-

Ubx3:mug39

CDC48-dependent degradation

UBX3

NSFL1C

Uch2

26S Ub-hydrolase

YUH1

UCHL3

Rpn12:mts3

19S regulatory protein

RPN12/NIN1

PSMD8

Ubx2:ucp13

CDC48-dependent degradation

UBX5

-

Rpn3

19S regulatory protein

RPN3/SUN2

PSMD3

SPCC4G3.13c

Cue1/4 domain

CUE1-4/KIS4

-

  1. a Modulated transcripts are reported for which at least a two-fold up-regulation was found.
  2. b The S. pombe wild-type sensitive strain 972 (h-, no auxotrophic markers) was exposed to a cisplatin concentration inhibiting colony growth by 80% (1.28 mM) after 4h drug exposure.