Insight into cross-talk between intra-amoebal pathogens

Gimenez, Gregory; Bertelli, Claire; Moliner, Claire; Robert, Catherine; Raoult, Didier; Fournier, Pierre-Edouard; Greub, Gilbert

doi:10.1186/1471-2164-12-542

BMC Genomics

Table 2 Potential horizontal gene transfers identified

From: Insight into cross-talk between intra-amoebal pathogens

Score	PAH-LLAP	PAH-Legionellales	Legionellales-Chlamydiales	PAH/LLAP-Rickettsiales	PAH/LLAP-Others	Gene product	COG accession	COG group
0	101					Hypothetical protein
	158					Choloylglycine hydrolase	COG3049	M
		191		191 PAH-Rickettsiales		Acetyltransferase	COG0454	KR
		192		192 PAH-Wolbachia		Aminoglycoside phosphotransferase family protein	COG3173	R
	473					putative phosphotransferase	COG2334	R
		475				Hypothetical protein	COG0500	QR
		492				Toluene efflux pump outer membrane protein	COG1538	MU
1		96				Conserved hypothetical protein	COG0599	S
	127					ABC-type multidrug transporter, permease	COG0842	V
	128					ABC-type multidrug transporter, ATP-binding protein	COG1131	V
	129					HlyD family secretion protein	COG0845	M
				243 LLAP-Rickettsia		Beta-lactamase	COG2602	V
		246				Acetyltransferase, GNAT family	COG0454	KR
		247				Hypothetical protein	COG2132	Q
			282			Conserved hypothetical protein	COG4804	S
		387		387 PAH-Legionellales-Orientia		Hypothetical protein	COG0500	QR
2		11				Succinylarginine dihydrolase	COG3724	E
		86				Metallo-beta-lactamase family protein	COG1234	R
		166				Multidrug resistance protein	COG0477	GEPR
			207		207 LLAP-Naegleria	7-dehydrocholesterol reductase	COG2020	O
		301				Acyl-CoA dehydrogenase	COG1960	I
				388 LLAP-Rickettsia		Aminoglycoside N(6')-acetyltransferase	COG1670	J
		400*				Putative transcriptional regulator	COG0583	K
		421				Putative outer membrane efflux protein	COG1538	MU
					458 Chlamydiales- Eukaryotes	Alpha keto acid dehydrogenase complex E1 component alpha subunit	COG1071	C
		474				DNA protection during starvation protein	COG0783	P
3			90			Multidrug resistance protein B homolog	COG0477	GEPR
	130					Solvent efflux pump outer membrane protein	COG1538	MU
				134 Chlamydiales-Ehrlichia/Wolbachia		Proton/sodium-glutamate symport protein	COG1301	C
					208 LLAP-A.asiaticus	PEBP family protein	COG1881	R
				211 PAH-Rickettsia		Putative 6-pyruvoyl tetrahydrobiopterin synthase	COG0720	H
					240 LLAP- Eukaryotes	Hypothetical protein	COG1092	R
			263	263 LLAP-Rickettsia		DNA protection during starvation protein 2	COG0783	P
				390 Legionellales-Rickettsiales		ABC-type transporter, permease and ATPase subunit	COG1132	V
		413				Cation-transporting ATPase	COG2217	P
		422*				Inner membrane transport permease YbhR	COG0842	V
		466*				Methylisocitrate lyase	COG2513	G

* clustering with Legionella pneumophila only, PAH = Parachlamydia acanthamoebae, LLAP = Legionella drancourtii
This table presents the classification by score and ID numbers of the L. drancourtii and P. acanthamoebae orthologues that exhibit a phylogenetic reconstruction suggesting horizontal gene transfer events. The gene product annotation, COG accession number and COG group are indicated for each gene.

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ISSN: 1471-2164

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