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Figure 1 | BMC Genomics

Figure 1

From: HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

Figure 1

Network of differentially expressed genes in HMGA1 transgenics at 2 months (nonparametric CAM approach). IPA was performed on microarray data comparing transgenic to control lymphoid cells from mice. Using 113 differentially expressed genes as the focus gene set identified by nonparametric analysis, the highest-scoring network was Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, and Inflammatory Response (score = 50). Red nodes indicate up-regulation; green nodes indicate down-regulation. Arrows and lines denote interactions between specific genes within the network. A, activation; E, expression regulation; I, inhibition; L, proteolysis; LO, localization; M, biochemical modification; MB, membership of a group or complex; P, phosphorylation; PD, protein-DNA interaction; PP, protein-protein interaction; PR, protein-RNA interaction; RB, regulation of binding; RE, reaction; T, transcription; TR, translocation.

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