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Table 3 Genes regulated 8 hours following dexamethasone treatment.

From: Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia

ProbeSet ID

Gene

t

P

FDR

Definition

Upregulated

     

ILMN_5080450

ZBTB16

83.77

< 2.2E-16

< 2.2E-16

zinc finger and BTB domain containing 16

ILMN_3800088

MMP7

53.22

< 2.2E-16

< 2.2E-16

matrix metallopeptidase 7

ILMN_1770593

CH25H

53.14

< 2.2E-16

< 2.2E-16

cholesterol 25-hydroxylase

ILMN_6560328

C6orf85

44.60

< 2.2E-16

< 2.2E-16

chromosome 6 open reading frame 85

ILMN_7570561

TSC22D3

39.16

< 2.2E-16

< 2.2E-16

TSC22 domain family, member 3

ILMN_580187

PDE8B

33.88

< 2.2E-16

3.90E-16

phosphodiesterase 8B

ILMN_5130066

C8orf61

33.82

< 2.2E-16

3.90E-16

chromosome 8 open reading frame 61

ILMN_4120431

TMEM100

31.38

< 2.2E-16

1.64E-15

transmembrane protein 100

ILMN_650553

BIN1

29.76

< 2.2E-16

4.43E-15

bridging integrator 1

ILMN_1400373

SLA

29.57

< 2.2E-16

4.63E-15

Src-like-adaptor

ILMN_6330593

PTHR1

29.28

< 2.2E-16

5.22E-15

parathyroid hormone receptor 1

ILMN_6110037

LILRA3

29.04

< 2.2E-16

5.75E-15

leukocyte immunoglobulin-like receptor subfamily A, member 3

ILMN_4150477

LOXL4

28.67

< 2.2E-16

6.66E-15

lysyl oxidase-like 4

ILMN_2680079

OGFRL1

28.65

< 2.2E-16

6.66E-15

opioid growth factor receptor-like 1

ILMN_4210411

NDRG2

28.20

< 2.2E-16

8.62E-15

NDRG family member 2

ILMN_3780093

LILRA1

27.86

< 2.2E-16

1.05E-14

leukocyte immunoglobulin-like receptor subfamily A, member 1

ILMN_240441

IL1R2

27.46

< 2.2E-16

1.33E-14

interleukin 1 receptor, type II

ILMN_4730315

MERTK

26.14

< 2.2E-16

3.31E-14

c-mer proto-oncogene tyrosine kinase

ILMN_3800538

ACPL2

25.90

< 2.2E-16

3.72E-14

acid phosphatase-like 2

ILMN_6860392

UGT2B17

25.83

< 2.2E-16

3.72E-14

UDP glucuronosyltransferase 2 family, polypeptide B17

ILMN_4730541

SLC44A1

25.82

< 2.2E-16

3.72E-14

solute carrier family 44, member 1

ILMN_4860546

CTHRC1

25.64

< 2.2E-16

4.10E-14

collagen triple helix repeat containing 1

ILMN_3460270

ZHX3

24.56

< 2.2E-16

8.79E-14

zinc fingers and homeoboxes 3

ILMN_10639

RASSF4

23.21

< 2.2E-16

2.57E-13

Ras association (RalGDS/AF-6) domain family 4

ILMN_1190064

UGT2B7

23.13

< 2.2E-16

2.67E-13

UDP glucuronosyltransferase 2 family, polypeptide B7

ILMN_6400603

MGC2463

23.06

< 2.2E-16

2.71E-13

poliovirus receptor related immunoglobulin domain containing

ILMN_3450187

IRGM

23.04

< 2.2E-16

2.71E-13

immunity-related GTPase family, M

ILMN_6620528

MT1X

22.95

2.40E-16

2.85E-13

metallothionein 1X

ILMN_1260341

IL13RA1

22.47

3.67E-16

4.13E-13

interleukin 13 receptor, alpha 1

ILMN_2650112

SLC16A2

22.25

4.48E-16

4.91E-13

solute carrier family 16, member 2

ILMN_5570170

PNMT

22.01

5.59E-16

5.95E-13

phenylethanolamine N-methyltransferase

ILMN_870376

C9orf152

21.93

6.02E-16

6.25E-13

chromosome 9 open reading frame 152

ILMN_3190379

TGFBR3

21.52

8.78E-16

8.89E-13

transforming growth factor, beta receptor III

ILMN_1780142

DSCR1

21.08

1.33E-15

1.31E-12

Down syndrome critical region gene 1

ILMN_2640341

FKBP5

20.63

2.05E-15

1.89E-12

FK506 binding protein 5

ILMN_7610136

LOC652626

20.43

2.48E-15

2.23E-12

Leukocyte immunoglobulin-like receptor subfamily B member 2

ILMN_1410609

CORO2A

20.34

2.72E-15

2.35E-12

coronin, actin binding protein, 2A

ILMN_1780088

TBXA2R

20.29

2.84E-15

2.40E-12

thromboxane A2 receptor

ILMN_270431

BAALC

20.23

3.02E-15

2.50E-12

brain and acute leukemia, cytoplasmic

ILMN_6280176

GBE1

20.02

3.72E-15

3.01E-12

glucan (1,4-alpha-), branching enzyme 1

ILMN_6060113

TBX15

19.81

4.62E-15

3.67E-12

T-box 15

ILMN_4890743

IQSEC1

19.71

5.09E-15

3.97E-12

IQ motif and Sec7 domain 1

ILMN_150056

DPEP1

19.65

5.41E-15

4.13E-12

dipeptidase 1

ILMN_2060364

BTNL9

19.26

8.04E-15

5.91E-12

butyrophilin-like 9

ILMN_3830735

UPB1

19.23

8.30E-15

5.91E-12

ureidopropionase, beta

ILMN_5670377

STYK1

19.15

9.09E-15

6.35E-12

serine/threonine/tyrosine kinase 1

ILMN_4390630

STAG3

18.72

1.42E-14

9.39E-12

stromal antigen 3

ILMN_4070048

NPHP4

18.44

1.91E-14

1.25E-11

nephronophthisis 4

ILMN_4220474

C6orf81

18.31

2.16E-14

1.39E-11

chromosome 6 open reading frame 81

ILMN_1470746

PTPN3

18.30

2.23E-14

1.41E-11

protein tyrosine phosphatase, non-receptor type 3

ILMN_5860576

C20orf133

18.25

2.36E-14

1.47E-11

MACRO domain containing 2

ILMN_6020468

PPP1R14A

18.18

2.52E-14

1.55E-11

protein phosphatase 1, regulatory (inhibitor) subunit 14A

ILMN_1400634

MT1M

18.10

2.76E-14

1.64E-11

metallothionein 1M

ILMN_4250315

ITGA9

17.90

3.46E-14

2.03E-11

integrin, alpha 9

ILMN_5080471

MAP3K6

17.40

6.02E-14

3.44E-11

mitogen-activated protein kinase 6

ILMN_5360242

FLJ42461

17.36

6.28E-14

3.53E-11

smoothelin-like 2

ILMN_6620402

NUDT16

17.33

6.50E-14

3.60E-11

nudix (nucleoside diphosphate linked moiety X)-type motif 16

ILMN_3360112

TMEM2

17.26

7.04E-14

3.85E-11

transmembrane protein 2

ILMN_6840743

PER1

17.22

7.41E-14

3.99E-11

period homolog 1

ILMN_4220347

LRRC1

17.12

8.29E-14

4.33E-11

leucine rich repeat containing 1

ILMN_4850592

P2RY14

17.11

8.35E-14

4.33E-11

purinergic receptor P2Y, G-protein coupled, 14

ILMN_6560300

SLC31A2

16.91

1.05E-13

5.39E-11

solute carrier family 31 member 2

ILMN_4060091

DKFZ

16.87

1.11E-13

5.62E-11

DKFZp451A211 protein

ILMN_6770370

LOC92196

16.28

2.23E-13

1.11E-10

death associated protein-like 1

ILMN_580487

IL9R

16.21

2.40E-13

1.18E-10

interleukin 9 receptor

ILMN_1990300

SOCS1

16.18

2.49E-13

1.21E-10

suppressor of cytokine signaling 1

ILMN_5720424

NRP1

16.17

2.54E-13

1.22E-10

neuropilin 1

ILMN_4180427

CIB4

16.11

2.74E-13

1.30E-10

calcium and integrin binding family member 4

ILMN_4180544

ROPN1L

16.08

2.81E-13

1.32E-10

ropporin 1-like

ILMN_4250167

SOX13

16.04

2.95E-13

1.37E-10

SRY (sex determining region Y)-box 13

ILMN_6330170

CHKA

15.81

3.94E-13

1.81E-10

choline kinase alpha, 3

ILMN_4560192

SFXN5

15.62

4.95E-13

2.25E-10

sideroflexin 5

ILMN_2810136

CAPN11

15.56

5.33E-13

2.40E-10

calpain 11

ILMN_2690709

VIPR1

15.38

6.68E-13

2.91E-10

vasoactive intestinal peptide receptor 1

ILMN_630091

NCOA7

15.38

6.69E-13

2.91E-10

nuclear receptor coactivator 7

ILMN_5390730

MGC17330

15.21

8.25E-13

3.55E-10

phosphoinositide-3-kinase interacting protein 1

ILMN_130364

MST150

15.19

8.49E-13

3.62E-10

MSTP150

ILMN_3450241

KIAA0774

14.95

1.16E-12

4.77E-10

KIAA0774

ILMN_2230678

ACACB

14.80

1.41E-12

5.76E-10

acetyl-Coenzyme A carboxylase beta

ILMN_5870307

LOC440359

14.78

1.44E-12

5.83E-10

similar to muscle Y-box protein YB2

ILMN_3840554

SPOCK2

14.76

1.49E-12

5.95E-10

sparc/osteonectin, cwcv and kazal-like domains 2

ILMN_5810600

MAP3K5

14.69

1.63E-12

6.47E-10

mitogen-activated protein kinase 5

ILMN_2360719

IRAK3

14.65

1.71E-12

6.65E-10

interleukin-1 receptor-associated kinase 3

ILMN_1510121

MTSS1

14.64

1.73E-12

6.66E-10

metastasis suppressor 1

ILMN_540671

LILRB2

14.54

1.98E-12

7.41E-10

leukocyte immunoglobulin-like receptor subfamily B, member 2

ILMN_6980377

MTMR15

14.44

2.26E-12

8.39E-10

myotubularin related protein 15

ILMN_6220288

PRDM1

14.43

2.28E-12

8.39E-10

PR domain containing 1, with ZNF domain

ILMN_7330739

NDRG4

14.42

2.30E-12

8.39E-10

NDRG family member 4

ILMN_2600470

WDR60

14.20

3.10E-12

1.12E-09

WD repeat domain 60

ILMN_4050441

SH3MD4

14.16

3.27E-12

1.17E-09

SH3 multiple domains 4

ILMN_6760546

TIPARP

13.89

4.74E-12

1.64E-09

TCDD-inducible poly(ADP-ribose) polymerase

ILMN_2760537

MTE

13.89

4.75E-12

1.64E-09

metallothionein E

ILMN_160019

SORT1

13.79

5.44E-12

1.83E-09

sortilin 1

ILMN_6330132

ISG20

13.60

7.00E-12

2.32E-09

interferon stimulated exonuclease gene 20 kDa

ILMN_1510685

DOK4

13.52

7.86E-12

2.58E-09

docking protein 4

ILMN_1240228

PAG1

13.47

8.50E-12

2.77E-09

phosphoprotein associated glycosphingolipid microdomains 1

ILMN_580592

CPNE8

13.32

1.04E-11

3.31E-09

copine VIII

ILMN_5870301

KIAA0513

13.32

1.05E-11

3.31E-09

KIAA0513

ILMN_20129

CD52

13.32

1.05E-11

3.31E-09

CD52 molecule

ILMN_1820386

PARVB

13.31

1.06E-11

3.31E-09

parvin, beta

ILMN_6200402

MT1A

13.24

1.17E-11

3.64E-09

metallothionein 1A

ILMN_290661

CLN8

13.10

1.43E-11

4.36E-09

ceroid-lipofuscinosis, neuronal 8

ILMN_670082

GNA12

13.08

1.47E-11

4.43E-09

guanine nucleotide binding protein (G protein) alpha 12

ILMN_5570286

TACC2

12.99

1.67E-11

5.00E-09

transforming, acidic coiled-coil containing protein 2

ILMN_3190411

STARD13

12.93

1.81E-11

5.32E-09

START domain containing 13

ILMN_4540138

NGB

12.92

1.85E-11

5.39E-09

neuroglobin

ILMN_2000646

B4GALT4

12.83

2.10E-11

6.07E-09

UDP-galactosyltransferase, polypeptide 4

ILMN_7100731

CYGB

12.81

2.17E-11

6.17E-09

cytoglobin

ILMN_7050113

NTRK1

12.71

2.52E-11

7.09E-09

neurotrophic tyrosine kinase receptor, type 1

ILMN_2490670

GNPTAB

12.66

2.71E-11

7.52E-09

N-acetylglucosamine-1-phosphate transferase, alpha and beta

ILMN_20170

ZNF385

12.48

3.55E-11

9.72E-09

zinc finger protein 385

ILMN_2630687

CHPT1

12.43

3.80E-11

1.02E-08

choline phosphotransferase 1

ILMN_4120215

WASF2

12.43

3.81E-11

1.02E-08

WAS protein family, member 2

ILMN_5260494

TMLHE

12.39

4.06E-11

1.08E-08

trimethyllysine hydroxylase, epsilon

ILMN_5220333

C14orf139

12.31

4.54E-11

1.20E-08

chromosome 14 open reading frame 139

ILMN_3850440

FCER1G

12.12

6.07E-11

1.60E-08

Fc fragment of IgE, receptor for; gamma polypeptide

ILMN_1030008

TGFB3

12.11

6.21E-11

1.63E-08

transforming growth factor, beta 3

ILMN_1450468

MYT1

12.02

7.04E-11

1.81E-08

myelin transcription factor 1

ILMN_7560541

SLC2A5

12.01

7.19E-11

1.83E-08

solute carrier family 2 member 5

ILMN_2030438

GBA2

12.01

7.21E-11

1.83E-08

glucosidase, beta (bile acid) 2

ILMN_6840328

SMAD3

12.00

7.35E-11

1.86E-08

SMAD family member 3

ILMN_3930390

SMAP1L

11.91

8.40E-11

2.11E-08

stromal membrane-associated protein 1-like

ILMN_7570196

TSPAN9

11.90

8.54E-11

2.12E-08

tetraspanin 9

ILMN_6980546

CACNA1I

11.90

8.56E-11

2.12E-08

calcium channel, voltage-dependent, T type, alpha 1I subunit

ILMN_1710364

LCN6

11.89

8.72E-11

2.15E-08

lipocalin 6

ILMN_5360424

RPS6KA2

11.77

1.04E-10

2.54E-08

ribosomal protein S6 kinase, 90 kDa, polypeptide 2

ILMN_5890193

MS4A4A

11.72

1.14E-10

2.75E-08

membrane-spanning 4-domains, subfamily A, member 4

ILMN_3390292

KLF9

11.66

1.24E-10

2.98E-08

Kruppel-like factor 9

ILMN_5720059

GFOD1

11.65

1.26E-10

3.02E-08

glucose-fructose oxidoreductase domain containing 1

ILMN_7650523

TMEM46

11.57

1.43E-10

3.39E-08

transmembrane protein 46

ILMN_5700392

LOC654000

11.46

1.70E-10

3.95E-08

ribosome biogenesis protein BMS1 homolog 2

ILMN_4810348

C1orf188

11.40

1.88E-10

4.33E-08

chromosome 1 open reading frame 188

ILMN_4280180

CHRNA3

11.39

1.91E-10

4.37E-08

cholinergic receptor, nicotinic, alpha 3

ILMN_270458

CRISPLD1

11.37

1.96E-10

4.45E-08

cysteine-rich secretory protein LCCL domain containing 1

ILMN_450615

MT2A

11.37

1.97E-10

4.46E-08

metallothionein 2A

ILMN_20470

GRASP

11.35

2.02E-10

4.51E-08

GRP1-associated scaffold protein

ILMN_3370594

LILRA2

11.35

2.03E-10

4.51E-08

leukocyte immunoglobulin-like receptor subfamily A, member 2

ILMN_5220397

RREB1

11.34

2.05E-10

4.53E-08

ras responsive element binding protein 1

ILMN_1410192

TDRD9

11.34

2.07E-10

4.56E-08

tudor domain containing 9

ILMN_4070259

LOC653133

11.27

2.30E-10

4.99E-08

guanine nucleotide binding protein (G protein) alpha 12

ILMN_5960682

RBPMS2

11.24

2.41E-10

5.21E-08

RNA binding protein with multiple splicing 2

ILMN_1440300

SLC27A3

11.22

2.50E-10

5.37E-08

solute carrier family 27, member 3

ILMN_5050768

LONRF1

11.20

2.58E-10

5.53E-08

LON peptidase N-terminal domain and ring finger 1

ILMN_6270273

KHDRBS3

11.18

2.67E-10

5.68E-08

KH domain, RNA binding, signal transduction associated 3

ILMN_7100603

KCNK3

11.17

2.70E-10

5.72E-08

potassium channel, subfamily K, member 3

ILMN_2320129

CSDA

11.03

3.38E-10

7.08E-08

cold shock domain protein A

ILMN_3930022

LOC644739

10.99

3.63E-10

7.54E-08

Wiskott-Aldrich syndrome protein family member 4

ILMN_7400133

CUGBP2

10.90

4.20E-10

8.63E-08

CUG triplet repeat, RNA binding protein 2

ILMN_3290301

FZD8

10.88

4.33E-10

8.76E-08

frizzled homolog 8

ILMN_7320520

MTUS1

10.88

4.33E-10

8.76E-08

mitochondrial tumor suppressor 1

ILMN_3780053

PALLD

10.82

4.79E-10

9.60E-08

palladin, cytoskeletal associated protein

ILMN_6860162

LOC441019

10.74

5.49E-10

1.09E-07

hypothetical LOC441019

ILMN_5810154

ALOX15B

10.74

5.50E-10

1.09E-07

arachidonate 15-lipoxygenase, type B

ILMN_3930736

CHST3

10.73

5.59E-10

1.09E-07

carbohydrate (chondroitin 6) sulfotransferase 3

ILMN_60470

STX11

10.72

5.68E-10

1.10E-07

syntaxin 11

ILMN_3390484

SERINC2

10.69

5.95E-10

1.15E-07

serine incorporator 2

ILMN_1430647

TAX1BP3

10.61

6.82E-10

1.31E-07

Tax1 (human T-cell leukemia virus type I) binding protein 3

ILMN_5960440

VDR

10.60

6.99E-10

1.34E-07

vitamin D (1,25-dihydroxyvitamin D3) receptor

ILMN_6290735

EPHB3

10.51

8.10E-10

1.53E-07

EPH receptor B3

ILMN_2680372

SH2D4A

10.46

8.78E-10

1.64E-07

SH2 domain containing 4A

ILMN_2480050

SOX7

10.44

9.13E-10

1.69E-07

SRY (sex determining region Y)-box 7

ILMN_130128

LOC285016

10.41

9.61E-10

1.76E-07

hypothetical protein LOC285016

ILMN_4890451

GRAMD3

10.39

9.87E-10

1.80E-07

GRAM domain containing 3

ILMN_770161

C10orf73

10.39

9.92E-10

1.81E-07

chromosome 10 open reading frame 73

ILMN_2450202

KIF3C

10.35

1.05E-09

1.88E-07

kinesin family member 3C

ILMN_6840468

HAL

10.35

1.06E-09

1.89E-07

histidine ammonia-lyase

ILMN_2470070

TBL1X

10.30

1.15E-09

2.04E-07

transducin (beta)-like 1X-linked

ILMN_2320114

KLF13

10.27

1.22E-09

2.15E-07

Kruppel-like factor 13

ILMN_6380112

DIP

10.23

1.31E-09

2.27E-07

death-inducing-protein

ILMN_2470358

IFNGR1

10.22

1.32E-09

2.30E-07

interferon gamma receptor 1

ILMN_4250735

IL27RA

10.07

1.70E-09

2.91E-07

interleukin 27 receptor, alpha

ILMN_1470215

MAP3K8

10.07

1.72E-09

2.91E-07

mitogen-activated protein kinase 8

ILMN_2940373

TACC1

10.06

1.74E-09

2.94E-07

transforming, acidic coiled-coil containing protein 1

Downregulated

     

ILMN_770538

LYSMD2

-15.49

5.81E-13

2.58E-10

LysM, putative peptidoglycan-binding, domain containing 2

ILMN_7150059

STAMBPL1

-14.61

1.79E-12

6.84E-10

STAM binding protein-like 1

ILMN_5340692

STRBP

-14.56

1.93E-12

7.31E-10

spermatid perinuclear RNA binding protein

ILMN_4210397

GLDC

-14.05

3.80E-12

1.34E-09

glycine dehydrogenase

ILMN_6980327

DKC1

-13.79

5.44E-12

1.83E-09

dyskeratosis congenita 1, dyskerin

ILMN_50086

TCF12

-13.23

1.19E-11

3.69E-09

transcription factor 12

ILMN_4860356

BYSL

-12.81

2.17E-11

6.17E-09

bystin-like

ILMN_4280228

IVNS1ABP

-12.70

2.55E-11

7.12E-09

influenza virus NS1A binding protein

ILMN_1990379

SLFN11

-11.82

9.63E-11

2.36E-08

schlafen family member 11

ILMN_5220338

MPEG1

-11.64

1.27E-10

3.03E-08

macrophage expressed gene 1

ILMN_450168

SFRS7

-11.50

1.60E-10

3.74E-08

splicing factor, arginine/serine-rich 7, 35 kDa

ILMN_3460687

KIAA0690

-11.42

1.81E-10

4.19E-08

ribosomal RNA processing 12 homolog

ILMN_3400360

MAPRE2

-11.36

1.99E-10

4.48E-08

microtubule-associated protein, RP/EB family, member 2

ILMN_4010414

PPFIBP1

-11.12

2.92E-10

6.16E-08

PTPRF interacting protein, binding protein 1 (liprin beta 1)

ILMN_1190139

UGT3A2

-10.99

3.61E-10

7.54E-08

UDP glycosyltransferase 3 family, polypeptide A2

ILMN_4150201

BCL2

-10.93

3.99E-10

8.24E-08

B-cell CLL/lymphoma 2

ILMN_780240

C12orf24

-10.85

4.53E-10

9.13E-08

chromosome 12 open reading frame 24

ILMN_6760167

MARCH3

-10.73

5.60E-10

1.09E-07

membrane-associated ring finger (C3HC4) 3

ILMN_3940615

PUS7

-10.52

7.99E-10

1.52E-07

pseudouridylate synthase 7 homolog

ILMN_20544

GART

-10.41

9.53E-10

1.76E-07

phosphoribosylglycinamide formyltransferase

ILMN_2480326

HSP90B1

-10.36

1.05E-09

1.88E-07

heat shock protein 90 kDa beta (Grp94), member 1

ILMN_5270367

CTSC

-10.25

1.26E-09

2.20E-07

cathepsin C

ILMN_5420095

MYC

-10.21

1.36E-09

2.34E-07

v-myc myelocytomatosis viral oncogene homolog

ILMN_4610180

PIK3C2B

-10.20

1.38E-09

2.37E-07

phosphoinositide-3-kinase, class 2, beta polypeptide

ILMN_6450300

GEMIN4

-10.00

1.95E-09

3.27E-07

gem (nuclear organelle) associated protein 4

  1. t, t-statistic; and FDR, false discovery rate
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BMC Genomics

ISSN: 1471-2164

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