A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

Table 5 PT-AT discriminative set and its extended set are significantly enriched by gene markers reported as potential biomarkers for a diagnostic of the early stages of lung AC. The extended set was obtained by relaxing the default PT-AT ECD signature at misclassification error values to 3. More details in see Additional file 4.

Early AC diagnostic signature genes from [7]^#	Supporting references^#	PT-AT extreme discriminative sign. (2829 genes)	Extended set (misclassification errors to 3)	EDGE
ATP10B	[7]	YES	YES	NO
AURKA	[5][7]	YES	YES	YES
CLDN5	[7]	YES	YES	YES
COL11A1	[10][7]	YES	YES	YES
DNAI2	[7]	NO	YES	NO
FABP6	[7]	NO	NO	NO
HIGD1B	[7]	YES	YES	YES
ILF3	[5][17][2]	YES	YES	NO
IQCG	[7]	NO	NO	NO
LRRC48	[7]	NO	NO	NO
LRRC50	[7]	NO	NO	NO
MCM6	[5][7]	YES	YES	NO
MUC4	[13][7]	NO	YES	NO
RARRES2	[7][3]	YES	YES	YES
RFTN1	[22][7][4][3]	YES	YES	NO
SCG5	[7]	YES	YES	NO
SCGB1A1	[9][7]	NO	YES	YES
SFTPA2	[7]	YES	YES	NO
SFTPB	[7]	NO	YES	NO
SFTPC	[7]	YES	YES	YES
TFPI2	[7]	YES	YES	YES
TM4SF4	[7]	NO	YES	NO
TOP2A	[5][7][6]	YES	YES	YES
XAGE1A	[14][7]	YES	YES	YES
XAGE1B	[24][21][14][7]	no U133A probe sets	no U133A probe sets	no U133A probe sets
XAGE1C	[14][7]	no U133A probe sets	no U133A probe sets	no U133A probe sets
XAGE1D	[14][7]	no U133A probe sets	no U133A probe sets	no U133A probe sets
XAGE1E	[14][7]	no U133A probe sets	no U133A probe sets	no U133A probe sets

# - The references mentioned in this table correspond to the citations used in Additional file 4.

ISSN: 1471-2164