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Table 3 The severe AD profile query correlates with other neurodegenerative condition transcriptional changes.

From: A searchable cross-platform gene expression database reveals connections between drug treatments and disease

Huntington's disease in various brain regions

 

Caudate nucleus

Cerebellum

Frontal cortex

 

r

N

r

N

r

N

severe

0.85

315

0.72

113

0.78

101

moderate

0.73

290

0.39

92

0.22

66

incipient

0.33

124

0.39

48

0.17

44

PD in various brain regions

 

SFG

LSN

MSN

 

r

N

r

N

r

N

severe

0.88

85

0.77

127

0.82

154

moderate

0.61

74

0.70

104

0.55

134

incipient

0.43

34

0.21

46

0.12

52

Down's Syndrome

 

Bipolar Disorder

 

r

N

  

r

N

severe

0.58

161

 

severe

0.87

139

moderate

0.68

202

 

moderate

0.58

73

incipient

0.04

112

 

incipient

0.03

44

  1. The correlation scores with the severe AD profile are shown for four distinct neurodegenerative conditions: Huntington's disease, Parkinson's disease, Down's syndrome and Bipolar disorder.