Figure 6

The association of epigenetic features after correcting for ChIP-seq input and nucleosome occupancy. (a) The distribution of ChIP-seq input around the splice sites of different types of AS events, the plotting method is the same as that in Figure 1c. (b-c) The distribution of Cluster 1 features (identified in Figure 4) corrected by nucleosome occupancy around the splice sites of different types of AS events in CD4+ cell line.*(d-i) The distribution of Cluster 1 features corrected by ChIP-seq input around the splice sites of different types of AS events in K562 cell line. (ES (exon skipping), ME (mutually exclusive exon), A5SS (alternative 5' splice site selection), A3SS (alternative 3' splice site selection), IR (intron retention)). * The nucleosome corrected signal level is low because the nucleosome occupancy has high signal level while the data of CD4+ are generate in 2007 and have less reads than other data source.